Li Yan

US Patent:

8618264, Dec 31, 2013

Filed:

Aug 19, 2009

Appl. No.:

13/062702

Inventors:

Mark Cunningham - Radnor PA, US
Yi Tang - Radnor PA, US
Li Yan - Berwyn PA, US

Assignee:

Centocor Ortho Biotech Inc. - Horsham PA

International Classification:

C07K 16/30

US Classification:

5303888, 5303873, 5303881

Abstract:

The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.

US Patent:

20050008638, Jan 13, 2005

Filed:

Jun 25, 2003

Appl. No.:

10/603313

Inventors:

Jin Lu - Boothwyn PA, US
Li Yan - Wayne PA, US
Chris Huang - Paoli PA, US
Marian Nakada - Malvern PA, US

International Classification:

C12Q001/68
C07H021/04
A61K039/395
C12N009/00
C07K016/40
C12P021/02
C12N005/06

US Classification:

424145100, 435006000, 536023200, 435069100, 435183000, 435320100, 435325000, 530388260

Abstract:

The present invention relates to at least one novel CNGH0005 polypeptides, antibodies, including isolated nucleic acids that encode at least one CNGH0005 polypeptide or antibody, CNGH0005 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

US Patent:

20050136451, Jun 23, 2005

Filed:

Oct 1, 2004

Appl. No.:

10/957503

Inventors:

Li Yan - Wayne PA, US
Chris Huang - Paoli PA, US
Prabakaran Kesavan - Blackwood NJ, US
Katherine Li - Wallingford PA, US
Marian Nakada - Malvern PA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/02

US Classification:

435006000, 435069100, 435189000, 435320100, 435325000, 530350000, 536023200

Abstract:

The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20050232923, Oct 20, 2005

Filed:

Nov 5, 2004

Appl. No.:

10/981936

Inventors:

Li Yan - Berwyn PA, US
Marian Nakada - Malvern PA, US
Anuk Das - Wayne PA, US

International Classification:

A61K039/395
A61K038/18
A61K038/54
A61K031/137
A61K031/473
A61K031/445
A61K031/573

US Classification:

424146100, 514012000, 514169000, 514297000, 514319000, 514649000

Abstract:

The present invention relates to methods for treating at least one MCP-1 related condition or pathology, including therapeutic compositions, methods and devices.

US Patent:

20130270489, Oct 17, 2013

Filed:

Apr 17, 2013

Appl. No.:

13/864499

Inventors:

Heraeus Precious Metals North America Conshohocken LLC - , US
Li Yan - West Conshohocken PA, US
Cuiwen Guo - Horsham PA, US
Weiming Zhang - Blue Bell PA, US

Assignee:

Heraeus Precious Metals North America Conshohocken LLC - West Conshohocken PA

International Classification:

H01L 31/0264

US Classification:

252514

Abstract:

The invention provides an inorganic reaction system for the preparation of electroconductive paste. Particularly, an inorganic reaction system comprises conductive glass. The inorganic reaction system may comprise a silver containing matrix forming composition. The silver containing matrix composition may comprise at least one of silver oxide or silver halide, or both. The invention also provides solar cells manufactured utilizing an electroconductive paste comprising an inorganic reaction system comprising conductive glass, and methods of manufacturing solar cells utilizing an electroconductive paste comprising an inorganic reaction system comprising conductive glass.

US Patent:

20140079711, Mar 20, 2014

Filed:

Nov 19, 2013

Appl. No.:

14/083762

Inventors:

Yi Tang - Radnor PA, US
Li Yan - Berwyn PA, US

Assignee:

Janssen Biotech, Inc. - Horsham PA

International Classification:

C07K 16/28
C07K 14/705

US Classification:

4241391, 435375, 4241851

Abstract:

The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.

US Patent:

59563540, Sep 21, 1999

Filed:

Jun 6, 1996

Appl. No.:

8/659855

Inventors:

Li Yan - Columbia MD

Assignee:

The University of Maryland Baltimore County - Baltimore MD

International Classification:

H01S 3098

US Classification:

372 18

Abstract:

In a two laser media, Nd:phosphate glass and Nd:YLF are combined into a single laser. Generally, one broad band inhomogeneously broadened material and one narrow band homogeneously broadened material, with the two materials having overlapping center wavelengths are suitable. ) The phase coherence property of Nd:YLF facilitates the initial formation of a coherent pulse. The broadband property of Nd:phosphate glass supports the generation of ultrashort laser pulse. Thus, this mode-locked hybrid Nd laser generates ultrashort coherent pulses more easily and reliably.

US Patent:

20200057066, Feb 20, 2020

Filed:

Mar 20, 2019

Appl. No.:

16/359286

Inventors:

- Boston MA, US
Li Yan - Berwyn PA, US

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

G01N 33/573
G01N 33/574
C12Q 1/37

Abstract:

Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs.