Binghui Shen - Glendora CA, US Li Zheng - Temple City CA, US
Assignee:
City of Hope - Duarte CA
International Classification:
C12Q 1/70 C12Q 1/68
US Classification:
435 5, 435 6
Abstract:
FEN-1 is involved in processing HIV central DNA flap (CDF) and is a target for intervention of HIV-1 replication. Inhibition of HIV-1 CDF removal by expression of D181A FEN-1 mutant suppresses viral DNA replication, further demonstrating that FEN-1 is a target. Methods of identifying and using molecules that inhibit FEN-1 processing HIV-1 CDF and other methods of inhibiting FEN-1 processing are provided. Useful small molecules specifically suppress FEN-1 cleavage of HIV CDF but have little effect on FEN-1's function in RNA-DNA primer removal. Pentamidine inhibits HIV replication by suppressing FEN-1-mediated HIV-CDF processing.
Methods And Compositions Comprising Tyrosine Kinase Inhibitor And Triptolide For The Treatment Of Cancer
Provided herein, inter alia, are methods, compositions and kits for treating cancer in a subject. The methods include administration of one or more tyrosine kinase inhibitors and triptolide or an analog thereof to the subject. The methods, compositions and kits are effective for preventing resistance and/or increasing sensitivity to tyrosine kinase inhibitors.
- Duarte CA, US - Pasadena CA, US Li Zheng - Arcadia CA, US Hongzhi Li - Duarte CA, US David Horne - Duarte CA, US Jun Xie - Duarte CA, US Kenneth Karanja - Maple Grove MN, US
International Classification:
C07D 215/56 A61K 45/06 A61K 31/47
Abstract:
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
- Duarte CA, US - Pasadena CA, US Li Zheng - Arcadia CA, US Hongzhi Li - Duarte CA, US David Horne - Duarte CA, US Jun Xie - Duarte CA, US Kenneth Karanja - Maple Grove MN, US
International Classification:
C07D 215/56 A61K 31/47 A61K 45/06
Abstract:
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
- Duarte CA, US - Pasadena CA, US Li Zheng - Arcadia CA, US Hongzhi Li - Duarte CA, US David Horne - Duarte CA, US Jun Xie - Duarte CA, US Kenneth Karanja - Maple Grove MN, US
International Classification:
C07D 215/56 A61K 31/47 A61K 45/06
Abstract:
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
Repair and Renovation of Concrete Structures: Proceedings of the International Conference Held at the University of Dundee, Scotland, UK on 5-7 July 2005