Liangqin Guo from 526 113Th St, New York, NY 10025, age 58

Resumes

Liangqin Guo

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Us Patents

Acylated Piperazine Derivatives As Melanocortin-4 Receptor Agonists
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US Patent:

7160886, Jan 9, 2007
Filed:

Feb 27, 2004
Appl. No.:

10/788859
Inventors:

Raman K. Bakshi - Edison NJ, US
Liangqin Guo - Edison NJ, US
Qingmei Hong - Scotch Plains NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Patrick G. Pollard - Oakhurst NJ, US
Iyassu K. Sebhat - New York NY, US
Feroze Ujjainwalla - Scotch Plains NJ, US
Zhixiong Ye - Princeton NJ, US
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 31/497
C07D 401/12
C07D 403/12
C07D 413/12
C07D 417/12
US Classification:

51425202, 51425211, 51425213, 51425214, 51425305, 51425306, 51425309, 51425401, 51425402, 51425403, 51425405, 5142541, 51425413, 544182, 544238, 544297, 544322, 544360, 544363, 544365, 544366, 544367, 544369, 544370, 544371, 544372, 544379
Abstract:

Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Bicyclic Piperidine Derivatives As Melanocortin-4 Receptor Agonists
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US Patent:

7276520, Oct 2, 2007
Filed:

Mar 22, 2004
Appl. No.:

10/548782
Inventors:

Ravi P. Nargund - East Brunswick NJ, US
Zhixiong Ye - Princeton NJ, US
Liangqin Guo - Edison NJ, US
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A01N 43/42
A61K 31/44
C07D 401/00
C07D 405/00
C07D 409/00
US Classification:

514304, 546125, 546112, 514299
Abstract:

Certain novel bicyclic N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated Spiropiperidine Derivatives As Melanocortin-4 Receptor Agonists
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US Patent:

7329673, Feb 12, 2008
Filed:

Mar 31, 2004
Appl. No.:

10/548350
Inventors:

Liangqin Guo - Edison NJ, US
Shuwen He - Edison NJ, US
Tianying Jian - Westfield NJ, US
Yingjie Lai - Edison NJ, US
Jian Liu - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Iyassu K. Sebhat - New York NY, US
Feroze Ujjainwalla - Scotch Plains NJ, US
Zhixiong Ye - Princeton NJ, US
Jonathan R. Young - Kendall Park NJ, US
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 31/438
C07D 221/20
C07D 401/02
US Classification:

514278, 546 17, 546 18
Abstract:

Certain novel N-acylated spiropiperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated Spiropiperidine Derivatives As Melanocortin-4 Receptor Modulators
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US Patent:

7652024, Jan 26, 2010
Filed:

Oct 13, 2006
Appl. No.:

12/083567
Inventors:

Raman K. Bakshi - Edison NJ, US
James P. Dellureficio - Millington NJ, US
Peter H. Dobbelaar - Morris Plains NJ, US
Liangqin Guo - Edison NJ, US
Shuwen He - Edison NJ, US
Qingmei Hong - Scotch Plains NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Zhixiong Ye - West Windsor NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A61K 31/438
C07D 491/107
US Classification:

514278, 546 17, 544125, 5142328
Abstract:

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated Piperidine Derivatives As Melanocortin 4-Receptor Agonists
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US Patent:

20080051430, Feb 28, 2008
Filed:

Jul 13, 2005
Appl. No.:

11/632001
Inventors:

Khaled Barakat - Brooklyn NY, US
Liangqin Guo - Edison NJ, US
Jian Liu - Edison NJ, US
Ravi Nargund - East Brunswick NJ, US
Iyassu Sebhat - New York NY, US
Zhixiong Ye - Princeton NJ, US
International Classification:

A61K 31/451
A61P 15/00
A61P 15/10
A61P 3/04
C07D 401/06
C07D 411/14
US Classification:

514316000, 514326000, 546189000, 546208000, 546210000
Abstract:

Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Beta Carboline Derivatives As Antidiabetic Compounds
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US Patent:

20100184758, Jul 22, 2010
Filed:

Jul 15, 2008
Appl. No.:

12/668822
Inventors:

Peter H. Dobbelaar - Morris Plains NJ, US
Wu Du - Monroe Township NJ, US
Liangqin Guo - Edison NJ, US
William K. Hagmann - Westfield NJ, US
Shuwen He - Edison NJ, US
Tianying Jian - Westfield NJ, US
Jian Liu - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Alexander Pasternak - Princeton NJ, US
Shrenik K. Shah - Metuchen NJ, US
Quang T. Truong - Morganville NJ, US
Zhixiong Ye - Princeton NJ, US
Raman Bakshi - Edison NJ, US
International Classification:

A61K 31/5377
C07D 471/14
A61K 31/437
C07D 413/14
C07D 403/14
A61K 31/501
A61K 31/4995
A61K 31/506
A61P 3/10
A61P 3/04
A61P 3/00
A61P 3/06
A61P 9/12
US Classification:

5142328, 546 84, 514292, 544126, 544238, 51425204, 544361, 51425303, 544333, 514256, 544315, 514274
Abstract:

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

Amino Cyclopentyl Heterocyclic And Carbocyclic Modulators Of Chemokine Receptor Activity
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US Patent:

20100234409, Sep 16, 2010
Filed:

May 20, 2005
Appl. No.:

11/596937
Inventors:

Lihu Yang - Edison NJ, US
Songnian Lin - Monroe NJ, US
Gregori Morriello - Randolph NJ, US
Liangqin Guo - Edison NJ, US
Changyou Zhou - Plainsboro NJ, US
International Classification:

A61K 31/438
C07D 401/10
C07D 211/32
C07D 235/04
C07D 215/04
A61K 31/445
A61K 31/454
A61K 31/4184
A61P 37/02
A61P 19/02
US Classification:

514278, 546 17, 546199, 5483047, 546 16, 514322, 514315, 514394
Abstract:

Compounds of the formulae (I) and (II): (wherein Q, X, E, G, G, R, R, R, R, Rand Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

Triazole Beta Carboline Derivatives As Anti-Diabetic Agents
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US Patent:

20110201615, Aug 18, 2011
Filed:

Oct 19, 2009
Appl. No.:

13/125319
Inventors:

Liangqin Guo - Edison NJ, US
Jian Liu - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Alexander Pasternak - Princeton NJ, US
Lihu Yang - Edison NJ, US
Zhixiong Ye - West Windsor NJ, US
International Classification:

A61K 31/501
C07D 471/04
A61K 31/437
C07D 401/14
A61K 31/506
A61P 3/00
A61P 9/12
US Classification:

51425204, 546 85, 514292, 544238, 544333, 514256
Abstract:

Beta-carboline derivatives of structural formula (I) are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

Liangqin Guo

Liangqin Guo Phones & Addresses

Resumes

Liangqin Guo

Us Patents

Acylated Piperazine Derivatives As Melanocortin-4 Receptor Agonists

Bicyclic Piperidine Derivatives As Melanocortin-4 Receptor Agonists

Acylated Spiropiperidine Derivatives As Melanocortin-4 Receptor Agonists

Acylated Spiropiperidine Derivatives As Melanocortin-4 Receptor Modulators

Acylated Piperidine Derivatives As Melanocortin 4-Receptor Agonists

Beta Carboline Derivatives As Antidiabetic Compounds

Amino Cyclopentyl Heterocyclic And Carbocyclic Modulators Of Chemokine Receptor Activity

Triazole Beta Carboline Derivatives As Anti-Diabetic Agents

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