Lifeng Geng

US Patent:

6335336, Jan 1, 2002

Filed:

Apr 28, 2000

Appl. No.:

09/561423

Inventors:

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Lifeng Geng - Skokie IL
Gunnar J. Hanson - Skokie IL
Richard A. Partis - Evanston IL
Michael A. Stealey - Libertyville IL
Richard M. Weier - Lake Bluff IL

Assignee:

G.D. Searle Company - Skokie IL

International Classification:

C07D40144

US Classification:

5142355, 5142372, 514255, 514318, 514341, 544124, 546193, 546194, 546211, 5462754

Abstract:

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I.

US Patent:

6423713, Jul 23, 2002

Filed:

Jul 31, 2001

Appl. No.:

09/918481

Inventors:

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Paul W. Collins - Deerfield IL
Joyce Zuowu Crich - Glenview IL
Rajesh Devraj - Ballwin MO
Daniel L. Flynn - Clarkson Valley MO
Lifeng Geng - Skokie IL
Matthew J. Graneto - Chesterfield MO
Cathleen E. Hanau - Chesterfield MO
Gunnar J. Hanson - Skokie IL
Susan J. Hartmann - Kirkwood MO
Michael Hepperle - St. Charles MO
He Huang - Chicago IL
Francis J. Koszyk - Prospect Heights IL
Shuyuan Liao - Glen Ellyn IL
Suzanne Metz - Chesterfield MO
Richard A. Partis - Evanston IL
Thao D. Perry - Chesterfield MO
Shashidhar N. Rao - St. Louis MO
Shaun Raj Selness - Chesterfield MO
Michael S. South - St. Louis MO
Michael A. Stealey - Libertyville IL
John Jeffrey Talley - St. Louis MO
Michael L. Vazquez - Ballwin MO
Richard M. Weier - Lake Bluff IL
Xiangdong Xi - Evanston IL
Ish K. Khanna - Libertyville IL
Yi Yu - Skokie IL

Assignee:

G. D. Searle Company - Skokie IL

International Classification:

A61K 31496

US Classification:

5142358, 51425301, 51425405, 514319, 514341, 544124, 544364, 546206, 546256, 5462754

Abstract:

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R , R , R and R are as described in the specification.

US Patent:

6514977, Feb 4, 2003

Filed:

Nov 20, 1998

Appl. No.:

09/196623

Inventors:

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Paul W. Collins - Deerfield IL
Joyce Zuowu Crich - Glenview IL
Rajesh Devraj - Ballwin MO
Daniel L. Flynn - Clarkson Valley MO
Lifeng Geng - Skokie IL
Matthew J. Graneto - Chesterfield MO
Cathleen E. Hanau - Chesterfield MO
Gunnar J. Hanson - Skokie IL
Susan J. Hartmann - Kirkwood MO
Michael Hepperle - St. Charles MO
He Huang - Chicago IL
Francis J. Koszyk - Prospect Heights IL
Shuyuan Liao - Glen Ellyn IL
Suzanne Metz - Chesterfield MO
Richard A. Partis - Evanston IL
Thao D. Perry - Chesterfield MO
Shashidhar N. Rao - St. Louis MO
Shaun Raj Selness - Chesterfield MO
Michael S. South - St. Louis MO
Michael A. Stealey - Libertyville IL
John Jeffrey Talley - St. Louis MO
Michael L. Vazquez - Ballwin MO
Richard M. Weier - Lake Bluff IL
Xiangdong Xu - Evanston IL
Ish K. Khanna - Libertyville IL
Yi Yu - Skokie IL

Assignee:

G.D. Searle Company - Skokie IL

International Classification:

A61K 31454

US Classification:

51425401, 544370, 544333, 546210, 514326

Abstract:

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R , R , R and R are as described in the specification.

US Patent:

6525059, Feb 25, 2003

Filed:

Feb 24, 2000

Appl. No.:

09/513351

Inventors:

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Paul W. Collins - Deerfield IL
Joyce Zuowu Crich - Glenview IL
Rajesh Devraj - Chesterfield MO
Daniel L. Flynn - Clarkson Valley MO
Lifeng Geng - Skokie IL
Matthew J. Graneto - Chesterfield MO
Cathleen E. Hanau - Chesterfield MO
Gunnar J. Hanson - Skokie IL
Susan J. Hartmann - Kirkwood MO
Michael Hepperle - St. Charles MO
He Huang - Chicago IL
Francis J. Koszyk - Prospect Heights IL
Shuyuan Liao - Northbrook IL
Suzanne Metz - Chesterfield MO
Richard A. Partis - Evanston IL
Thao D. Perry - Chesterfield MO
Shashidhar N. Rao - Mundelein IL
Shaun Raj Selness - St. Louis MO
Michael S. South - St. Louis MO
Michael A. Stealey - Libertyville IL
John Jeffrey Talley - St. Louis MO
Michael L. Vazquez - Ballwin MO
Richard M. Weier - Lake Bluff IL
Xiangdong Xu - Gurnee IL
Ish K. Khanna - Libertyville IL
Yi Yu - Skokie IL

Assignee:

G. D. Searle Company - Skokie IL

International Classification:

A61K 31506

US Classification:

514256, 544333, 544335

Abstract:

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R , R , R and R are as described in the specification.

US Patent:

6579873, Jun 17, 2003

Filed:

Dec 18, 2001

Appl. No.:

10/024071

Inventors:

Ashok Anantanarayan - Hainesville IL
Michael Clare - Skokie IL
Lifeng Geng - Skokie IL
Gunnar J. Hanson - Skokie IL
Richard A. Partis - Evanston IL
Michael A. Stealey - Libertyville IL
Richard M. Weier - Lake Bluff IL

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61K 3144

US Classification:

5142355, 514341, 514314, 544124, 5462754, 546152

Abstract:

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I wherein R , R , Ar and HetAr are as described in the specification.

US Patent:

6617324, Sep 9, 2003

Filed:

Apr 2, 2002

Appl. No.:

10/114297

Inventors:

Ashok S. Naraian - Hainesville IL
Michael Clare - Skokie IL
Paul W. Collins - Deerfield IL
Joyce Zuowu Crich - Glenview IL
Rajesh Devraj - Ballwin MO
Daniel L. Flynn - Clarkson Valley MO
Lifeng Geng - Skokie IL
Matthew J. Graneto - Chesterfield MO
Cathleen E. Hanau - Chesterfield MO
Gunnar J. Hanson - Skokie IL
Susan J. Hartmann - Kirkwood MO
Michael Hepperle - St. Charles MO
He Huang - Chicago IL
Francis J. Koszyk - Prospect Heights IL
Shuyuan Liao - Glen Ellyn IL
Suzanne Metz - Chesterfield MO
Richard A. Partis - Evanston IL
Thao D. Perry - Chesterfield MO
Shashidhar N. Rao - St. Louis MO
Shaun Raj Selness - Chesterfield MO
Michael S. South - St. Louis MO
Michael A. Stealey - Libertyville IL
John Jeffrey Talley - St. Louis MO
Michael L. Vazquez - Ballwin MO
Richard M. Weier - Lake Bluff IL
Xiangdong Xi - Evanston IL
Ish K. Khanna - Libertyville IL
Yi Yu - Skokie IL

Assignee:

G. D. Searle Company - Skokie IL

International Classification:

A61K 31496

US Classification:

5142358, 51425301, 51425405, 514319, 514341, 544124, 544364, 546206, 546256, 5462754

Abstract:

A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R , R , R and R are as described in the specification.

US Patent:

6849653, Feb 1, 2005

Filed:

Sep 19, 2002

Appl. No.:

10/247021

Inventors:

Michael Clare - Skokie IL, US
Lifeng Geng - Skokie IL, US
Gunnar J. Hanson - Skokie IL, US
He Huang - Northbrook IL, US
Donna M. Iula - Palatine IL, US
Shuyuan Liao - Northbrook IL, US
Michael A. Stealey - Libertyville IL, US
Richard M. Weier - Lake Bluff IL, US
Suzanne Metz - Chesterfield MO, US
Michael L. Vazquez - Ballwin MO, US

Assignee:

Pharmacia Corporation - Peapack NJ

International Classification:

A61K 31416
C07D23154

US Classification:

514406, 5483591, 549434, 549435

Abstract:

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

US Patent:

6956052, Oct 18, 2005

Filed:

Sep 19, 2002

Appl. No.:

10/247096

Inventors:

Arija A. Bergmanis - Des Plaines IL, US
Michael Clare - Skokie IL, US
Joyce Z. Crich - Glenview IL, US
Lifeng Geng - Skokie IL, US
Timothy J. Hagen - Gurnee IL, US
Gunnar J. Hanson - Skokie IL, US
Stephen C. Houdek - Des Plaines IL, US
He Huang - Northbrook IL, US
Donna M. Iula - Palatine IL, US
Francis J. Koszyk - Prospect Heights IL, US
Shuyuan Liao - Northbrook IL, US
Scott B. Mohler - Chicago IL, US
Maria Nguyen - Morton Grove IL, US
Richard A. Partis - Evanston IL, US
Michael A. Stealey - Libertyville IL, US
Michael B. Tollefson - Hainesville IL, US
Richard M. Weier - Lake Bluff IL, US
Xiangdong Xu - Gumee IL, US
Dominique Bonafoux - Saint Louis MO, US
Theresa R. Fletcher - Kirkwood MO, US
Bruce C. Hamper - Kirkwood MO, US
Patrick J. Lennon - Webster Groves MO, US
Subo Liao - Ballwin MO, US
Suzanne Metz - Chesterfield MO, US
David S. Oburn - Ferguson MO, US
Thomas J. Owen - Chesterfield MO, US
Angela M. Scates - Des Peres MO, US
Michael L. Vazquez - Ballwin MO, US
Serge G. Wolfson - Chesterfield MO, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61K031/416
C07D231/54

US Classification:

514406, 5483591, 5462681, 5462757

Abstract:

The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.