Lifeng Lin

US Patent:

20190085374, Mar 21, 2019

Filed:

Aug 31, 2018

Appl. No.:

16/120045

Inventors:

- Carlsbad CA, US
Timothy LOONEY - Redwood City CA, US
Lifeng LIN - Daly City CA, US
Elizabeth LINCH - Menifee CA, US
Lauren MILLER - San Diego CA, US

International Classification:

C12Q 1/686
C12Q 1/6806
C12Q 1/6869
C40B 50/00

Abstract:

The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

US Patent:

20180208984, Jul 26, 2018

Filed:

Jan 17, 2018

Appl. No.:

15/873862

Inventors:

- Carlsbad CA, US
Geoffrey LOWMAN - Carlsbad CA, US
Lifeng LIN - Daly City CA, US

International Classification:

C12Q 1/6876
C12Q 1/6869
C12Q 1/6844
C12Q 1/6811

Abstract:

The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.