Liliana S Staleva

US Patent:

7378232, May 27, 2008

Filed:

May 9, 2003

Appl. No.:

10/435439

Inventors:

Seth J. Orlow - New York NY, US
Prashiela Manga - Cincinnati OH, US
Liliana Staleva - New York NY, US

Assignee:

New York University - New York NY

International Classification:

C12Q 1/00
C12Q 1/02

US Classification:

435 4, 435 29

Abstract:

The invention provides methods for the identification of agents that modify or mimic P protein function. Cells expressing a P protein are generally more sensitive to toxins, and changes in cell viability and/or cell death after exposure of P protein-expressing cells to an agent and a toxin is an indication that such an agent is a modifier of P protein expression. The invention also provides methods for the treatment of melanoma and other cancers.