Lily Zhao Li

US Patent:

20040121305, Jun 24, 2004

Filed:

Dec 18, 2002

Appl. No.:

10/323493

Inventors:

Roger Wiegand - Wayland MA, US
Robert McCarroll - Lexington MA, US
Lily Li - Lexington MA, US
Dong Wei - Malden MA, US
Merce Crosas - Lexington MA, US
James Rogers - Hingham MA, US
Alexander Rosenberg - Brookline MA, US

International Classification:

C12Q001/00

US Classification:

435/004000

Abstract:

The invention provides methods of generating small molecule efficacy profiles and signature, small molecule toxicity profiles and signatures and small molecule disease profiles and signatures. The invention also provides methods of determining the efficacy and/or toxicity of unknown agents and drugs in a subject and methods of diagnosing an unknown disease or disorder in a subject. The invention further provides methods of monitoring the progression or remission of a disease or disorder in a subject undergoing treatment and methods of measuring the effectiveness of treatment.

US Patent:

20200088746, Mar 19, 2020

Filed:

Apr 25, 2019

Appl. No.:

16/394017

Inventors:

- Cambridge MA, US
Renta Hutabarat - Cambridge MA, US
Rene Alvarez - Cambridge MA, US
Bob Xiong - Cambridge MA, US
Lily Y.T. Li - Cambridge MA, US

International Classification:

G01N 33/78
G01N 33/68
G01N 30/72
C07K 14/575
C12Q 1/37
G01N 33/58

Abstract:

The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.

US Patent:

20170045536, Feb 16, 2017

Filed:

Oct 28, 2016

Appl. No.:

15/338006

Inventors:

- Cambridge MA, US
Renta Hutabarat - Cambridge MA, US
Rene Alvarez - Cambridge MA, US
Bob Xiong - Cambridge MA, US
Lily Y.T. Li - Cambridge MA, US

International Classification:

G01N 33/78
G01N 30/72

Abstract:

The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.

US Patent:

20140315231, Oct 23, 2014

Filed:

Nov 16, 2012

Appl. No.:

14/358139

Inventors:

- Cambridge MA, US
Renta Hutabarat - Cambridge MA, US
Rene Alvarez - Cambridge MA, US
Bob Xiong - Cambridge MA, US
Lily Y.T. Li - Cambridge MA, US

International Classification:

G01N 33/78
C07K 14/575
G01N 33/58
C12Q 1/37

US Classification:

435 23, 530300, 530326, 530327

Abstract:

The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.