Lin Chen

US Patent:

20230126413, Apr 27, 2023

Filed:

Apr 7, 2021

Appl. No.:

17/918031

Inventors:

- Baltimore MD, US
Peter VAN ZIJL - Hanover MD, US
Lin CHEN - Baltimore MD, US
Kannie Wai Yan CHAN - Hong Kong, CN
Jianpan HUANG - Hong Kong, CN

Assignee:

The Johns Hopkins University - Baltimore MD
Kennedy Krieger Institute, Inc. - Baltimore MD
City University of Hong Kong - Kowloon Tong

International Classification:

A61B 5/055
G01R 33/565

Abstract:

A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.

US Patent:

20140220527, Aug 7, 2014

Filed:

Feb 6, 2014

Appl. No.:

14/174372

Inventors:

Baoxin Li - Chandler AZ, US
Peng Zhang - Tempe AZ, US
Qiang Zhang - Tempe AZ, US
Lin Chen - Tempe AZ, US

Assignee:

AZ Board of Regents, a body corporate of the State of AZ, acting for & on behalf of AZ State - Scottsdale AZ

International Classification:

G09B 9/00

US Classification:

434262

Abstract:

An intelligent system that supports real-time and offline feedback based on automated analysis of a trainee's performance using data streams captured in the training process is disclosed.