Lin F Chen

US Patent:

6849426, Feb 1, 2005

Filed:

Jun 28, 2002

Appl. No.:

10/183992

Inventors:

Lin Chen - Frederick MD, US
Michael Pepe - Frederick MD, US

Assignee:

Cambrex Bio Science Walkersville, Inc. - Walkersville MD

International Classification:

C12P 2106

US Classification:

435 691

Abstract:

A reagent containing a purified horseshoe crab Factor C, particularly a recombinantly produced Factor C, and a surfactant can be used in a sensitive, rapid, and reproducible assay to detect endotoxin.

US Patent:

8352215, Jan 8, 2013

Filed:

Oct 23, 2009

Appl. No.:

12/604631

Inventors:

Lin (Colin) Chen - Rockville MD, US
Steve Krueger - Raleigh NC, US
Christopher D. Bailey - Cary NC, US

Assignee:

SAS Institute Inc. - Cary NC

International Classification:

G06F 17/18
G06F 19/00

US Classification:

702179

Abstract:

Systems and methods are provided for performing an estimation using an iteratively reweighted least squares technique on a scenario defined by a design matrix, a response variable vector, and a parameter to be estimated. A system and method can be configured to include a root data processor, where a least squares estimate is calculated by the root data processor during each of a plurality of processing iterations. A plurality of node data processors can also be configured to: update values of a weight matrix according to a current state of the least squares estimate, determine a first intermediate value based on the design matrix and the weight matrix, determine a second intermediate value based on the design and weight matrices and the response variable vector. The root data processor calculates an updated least squares estimate based on the intermediate values.

US Patent:

20040235080, Nov 25, 2004

Filed:

Jun 25, 2004

Appl. No.:

10/480254

Inventors:

Lin Chen - Frederick MD, US
Michael Pepe - Frederick MD, US

International Classification:

C12Q001/37
C12Q001/18

US Classification:

435/023000, 435/032000

Abstract:

A reagent containing a purified horseshoe crab Factor C, Particularly a recombinantly produced Factor C, and a surfactant can be used in a sensitive, rapid, and reproducible assay to detect endotoxin.