Lin Fanying M Chen

US Patent:

6569661, May 27, 2003

Filed:

Nov 9, 2000

Appl. No.:

09/711202

Inventors:

Minmin Qin - Pleasanton CA
Lin Chen - San Francisco CA
Paul A. Fitzpatrick - Albany CA
John M. Hendstrand - Davis CA
Dan J. Wendt - Walnut Creek CA
Gary N. Zecherle - Novato CA
Christopher M. Starr - Sonoma CA
Emil D. Kakkis - Novato CA

Assignee:

BioMarin Pharmaceutical Inc. - Novato CA

International Classification:

C12Q 100

US Classification:

435200, 435 4, 435183, 530350, 530412, 530416

Abstract:

The present invention provides a recombinant human -L-iduronidase and biologically active fragments and mutants thereof, large scale methods to produce and purify commercial grade recombinant human -L-iduronidase enzyme as well as methods to treat certain genetic disorders including -L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).

US Patent:

6866844, Mar 15, 2005

Filed:

Nov 7, 2002

Appl. No.:

10/290908

Inventors:

Minmin Qin - Pleasanton CA, US
John M. Henstrand - Davis CA, US
Gary N. Zecherle - Novato CA, US
Dan J. Wendt - Walnut Creek CA, US
Lin Chen - San Francisco CA, US
Paul A. Fitzpatrick - Albany CA, US
Christopher M. Starr - Sonoma CA, US

Assignee:

Biomarin Pharmaceutical Inc. - Novato CA

International Classification:

A61K038/46
C12N009/16
C12N001/20
C12N015/00
A23J001/00

US Classification:

424 946, 435196, 4352523, 4353201, 435536, 435 232, 435530, 435412

Abstract:

The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.

US Patent:

6972124, Dec 6, 2005

Filed:

Nov 7, 2003

Appl. No.:

10/704365

Inventors:

Minmin Qin - Pleasanton CA, US
Gary N. Zecherle - Novato CA, US
Paul A. Fitzpatrick - Albany CA, US
John M. Henstrand - Oakland CA, US
Dan J. Wendt - Walnut Creek CA, US
Lin Chen - San Francisco CA, US
Christopher M. Starr - Sonoma CA, US

Assignee:

BioMarin Pharmaceuticals Inc. - Novato CA

International Classification:

A61K038/46
C12N009/16
C12N001/20
C12N005/00
A23J001/00

US Classification:

424 946, 435196, 4352523, 4353201, 536 232, 530412

Abstract:

The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.

US Patent:

7591555, Sep 22, 2009

Filed:

Sep 2, 2008

Appl. No.:

12/230593

Inventors:

Lin Yun Chen - Foster City CA, US

International Classification:

G02C 5/22

US Classification:

351137, 351 76, 351106, 351136

Abstract:

A framework of combination of spectacle frames with lenses comprises a spectacle frame provided with an upper arm and assembled with a nosepiece, in which a hole seat is formed between the upper arm and the nosepiece and a wedge hole is formed inside the hole seat; a lens provided with a neck, in which adjustment of multiple segments may be made for clamping by using a gibbous wedge of the nosepiece that is arranged in the wedge hole, and a distance between the gibbous wedge and the upper arm may be adjusted for the tight fitness of lens. The lens may be easily assembled into the spectacle frame, and the issue on adjustment of fitness without any segment due to easy assembly.

US Patent:

7795761, Sep 14, 2010

Filed:

Dec 19, 2008

Appl. No.:

12/317223

Inventors:

Steven Huynh - Fremont CA, US
Matthew A. Grant - Palo Alto CA, US
Lin Chen - Mountain View CA, US

Assignee:

Active-Semi, Inc.

International Classification:

H01H 9/54

US Classification:

307140

Abstract:

A power converter having a switched capacitor buck/boost operation has first and second switches coupled to a first switching node, third and fourth switches coupled to a second switching node, a capacitor coupled between the first and second switching nodes, and an inductor coupled to the first switching node. A switch controller controls the switches to operate in voltage step-down mode and voltage step-up mode depending on a difference between converter output voltage VOUT and converter input voltage VIN. In a buck-optimized topology operating in a step-down mode, an output current flowing through the first switching node flows through only one switch at a given time. In a boost-optimized topology operating in a step-up mode, an output current flowing through the first switching node flows through only one switch at a given time. As a result, a more compact and efficient power converter may be realized at lower cost.

US Patent:

7853591, Dec 14, 2010

Filed:

Jun 30, 2006

Appl. No.:

11/428205

Inventors:

Xiaosong Yang - Palo Alto CA, US
Lin Chen - San Jose CA, US
Changming Liu - Cupertino CA, US

Assignee:

Juniper Networks, Inc. - Sunnyvale CA

International Classification:

G06F 7/00

US Classification:

707736, 707953, 711129, 711170, 711173

Abstract:

A system protects database operations performed on a shared resource. The system may chunk memory to form a set of memory chunks which have memory blocks, at least some of the memory blocks including database objects. The system may configure at least one binary search tree using the memory chunks as nodes and buffer a set of pointers corresponding to the memory blocks. The system may further validate the buffered pointers and dereference validated buffered pointers.

US Patent:

8176526, May 8, 2012

Filed:

Nov 20, 2006

Appl. No.:

11/561710

Inventors:

Xiaosong Yang - Palo Alto CA, US
Lin Chen - San Jose CA, US

Assignee:

Juniper Networks, Inc. - Sunnyvale CA

International Classification:

G06F 17/00

US Classification:

726 1, 726 2

Abstract:

Techniques are described for managing failover in redundant network devices. In particular, each device in a set of redundant network devices includes redundant processing modules. Each module provides a separate operating environment for a set of network services. Each network device includes a control unit that receives configuration information that specifies individual weight values for each of the modules and a threshold value for the network device. The control unit detects failures of the modules and transfers primary responsibility for performing the network service to a second network device when the threshold value is exceeded by a weighted sum of the weight values for the failed modules.

US Patent:

8260780, Sep 4, 2012

Filed:

Nov 4, 2010

Appl. No.:

12/939555

Inventors:

Xiaosong Yang - Palo Alto CA, US
Lin Chen - San Jose CA, US
Changming Liu - Cupertino CA, US

Assignee:

Juniper Networks, Inc. - Sunnyvale CA

International Classification:

G06F 7/00

US Classification:

707736, 707953, 711129, 711170, 711173

Abstract:

A system protects database operations performed on a shared resource. The system may chunk memory to form a set of memory chunks which have memory blocks, at least some of the memory blocks including database objects. The system may configure at least one binary search tree using the memory chunks as nodes and buffer a set of pointers corresponding to the memory blocks. The system may further validate the buffered pointers and dereference validated buffered pointers.