Lin J He

US Patent:

6579721, Jun 17, 2003

Filed:

Nov 13, 2000

Appl. No.:

09/711748

Inventors:

Michael J. Natan - Los Altos CA
David J. Pena - State College PA
Glenn Goodrich - State College PA
Lin He - Mountain View CA
L. Andrew Lyon - Marietta GA
Michael D. Musick - Huntingdon Valley PA
William D. Holliway - Atlanta GA

Assignee:

SurroMed, Inc. - Palo Alto CA

International Classification:

G01N 2165

US Classification:

436164, 436525, 356445

Abstract:

The invention provides methods and reagents for the enhancement of surface plasmon resonance (SPR)-based detection assays. The methods and reagents can be used in any molecular recognition assay that uses a solid support. The invention also provides an SPR instrument that operates in imaging mode.

US Patent:

6579726, Jun 17, 2003

Filed:

Jul 31, 2000

Appl. No.:

09/629790

Inventors:

Michael J. Natan - Los Altos CA
Glenn Goodrich - State College PA
Lin He - Mountain View CA
L. Andrew Lyon - Marietta GA
Michael D. Musick - Huntingdon Valley PA
Christine D. Keating - Lemont PA

Assignee:

SurroMed, Inc. - Mountain View CA

International Classification:

G01N 33543

US Classification:

436518, 385 12, 385129, 385130, 385131, 422 55, 422 57, 422 58, 422 8205, 422 8211, 435 6, 4352871, 4352872, 4352879, 4352887, 435808, 436164, 436165, 436524, 436525, 436527, 436805

Abstract:

The invention provides methods and reagents for the enhancement of surface plasmon resonance (SPR)-based detection assays. The methods and reagents can be used in any molecular recognition assay that uses a solid support. The invention also provides an SPR instrument that operates in imaging mode.

US Patent:

8071559, Dec 6, 2011

Filed:

May 2, 2006

Appl. No.:

11/416854

Inventors:

Gregory J. Hannon - Huntington NY, US
Scott Hammond - Pittsboro NC, US
Lin He - Cold Spring Harbor NY, US
John Michael Thomson - Apex NC, US
Summer Goodson - Chapel Hill NC, US

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
University of North Carolina - Chapel Hill NC

International Classification:

A61K 31/70
C07H 21/02
C07H 21/04
C12Q 1/68

US Classification:

514 44A, 536 231, 536 241, 536 245

Abstract:

The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

US Patent:

8399248, Mar 19, 2013

Filed:

May 5, 2008

Appl. No.:

12/598563

Inventors:

Michele A. Cleary - Jamison PA, US
Aimee L. Jackson - Carlsbad CA, US
Peter S. Linsley - Encinitas CA, US
Julja Burchard - San Francisco CA, US
Lee P. Lim - San Francisco CA, US
Jill F. Magnus - Seattle WA, US
Lin He - Berkeley CA, US
Xingyue He - Cambridge MA, US
Scott W. Lowe - Cold Spring Harbor NY, US
Gregory J. Hannon - Hungtington NY, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C12N 15/85
C07H 21/04
C07H 21/02

US Classification:

435325, 536 231, 536 245

Abstract:

In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.

US Patent:

20120207723, Aug 16, 2012

Filed:

Feb 9, 2012

Appl. No.:

13/369997

Inventors:

Lin He - Berkeley CA, US
Yong Jin Choi - Oakland CA, US
Gregory J. Hannon - Cold Spring Harbor NY, US
Xingyue He - Cambridge MA, US

International Classification:

A61K 35/12
C12N 5/10
C12N 5/071

US Classification:

424 9321, 435366, 435377, 424 937

Abstract:

The present disclosure provides a method of generating an induced pluripotent stem cell; as well as nucleic acids and genetically modified host cells useful in generating iPSCs. The present disclosure provides iPSCs, and methods of use of same.

US Patent:

20140041056, Feb 6, 2014

Filed:

Aug 22, 2012

Appl. No.:

13/591512

Inventors:

Dirk Stoop - Menlo Park CA, US
Jorn Van Dijk - San Francisco CA, US
Lin He - Mountain View CA, US

International Classification:

G06F 21/24

US Classification:

726 28

Abstract:

In one embodiment, a method includes receiving a designation of one or more items of digital media; receiving a communication regarding the one or more items of digital media; associating the one or more items of digital media with the communication based on the designation; and setting a privacy level for the communication and the one or more items of digital media on a social-networking system based on a privacy setting of a user on the social-networking system.

US Patent:

20210278367, Sep 9, 2021

Filed:

May 24, 2021

Appl. No.:

17/327806

Inventors:

- Oakland CA, US
Lin He - Berkeley CA, US
Andrew J. Modzelewski - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 27/447
C08K 5/1545
C08J 9/40
C08L 33/26

Abstract:

Dual nucleic acid and protein isoform measurements are performed on low starting cell numbers (e.g. equivalent to the number of blastomeres composing early embryonic development stages (morula and blastocysts)), comprising integrating fractionation polyacrylamide gel electrophoresis (fPAGE) of 10-100 cells with off-chip analysis of nucleic acids in the nuclei.

US Patent:

20190236311, Aug 1, 2019

Filed:

Jan 9, 2019

Appl. No.:

16/243979

Inventors:

- Menlo Park CA, US
Jorn Martinus Johannes van Dijk - Amsterdam, NL
Lin He - Los Altos CA, US

International Classification:

G06F 21/62

Abstract:

Techniques to allow for ease of navigation within a photo browsing interface of a social networking system. In one embodiment, a designation of a first image for sharing is received from within at least one of a single-image view and a camera view. Based on the designation, the first image is added to a communication. The designation may be based on a user selection of an option provided by an interface of a mobile device. The first image may be received from within a social networking application or from within a dedicated camera application. In another embodiment, the privacy level of the communication and the designated images is based on the privacy setting of a user. The communication and the designated images may contain tag data identifying one or more people on a social networking system. In an alternative embodiment, the privacy level of the communication and designated images is adjusted according to the one or more people identified in the tag data.