Lin He

US Patent:

8399248, Mar 19, 2013

Filed:

May 5, 2008

Appl. No.:

12/598563

Inventors:

Michele A. Cleary - Jamison PA, US
Aimee L. Jackson - Carlsbad CA, US
Peter S. Linsley - Encinitas CA, US
Julja Burchard - San Francisco CA, US
Lee P. Lim - San Francisco CA, US
Jill F. Magnus - Seattle WA, US
Lin He - Berkeley CA, US
Xingyue He - Cambridge MA, US
Scott W. Lowe - Cold Spring Harbor NY, US
Gregory J. Hannon - Hungtington NY, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C12N 15/85
C07H 21/04
C07H 21/02

US Classification:

435325, 536 231, 536 245

Abstract:

In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.

US Patent:

20020186764, Dec 12, 2002

Filed:

Apr 6, 2001

Appl. No.:

09/828324

Inventors:

Moeness Amin - Berwyn PA, US
Lin He - Rosemont PA, US
Yimin Zhang - Drexel Hill PA, US

Assignee:

Sarnoff Corporation

International Classification:

H03K005/159
H03H007/30
H03H007/40
H04B001/10

US Classification:

375/233000, 375/350000

Abstract:

A method and apparatus for equalizing a radio frequency (RF) signal includes a modified constant modulus algorithm (M-CMA) that performs blind equalization on the input channel. The M-CMA uses both amplitude and phase information present in the output signal to minimize a cost function and adjust the tap weights of an equalizer using a gradient recursion equation. Use of both amplitude and phase information results in quicker convergence and faster tracking of dynamic distortions in the input channel in severe multipath environments.