Lin Hai Li

US Patent:

7309792, Dec 18, 2007

Filed:

Mar 1, 2005

Appl. No.:

11/070733

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Dallas TX, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
C07D 257/04
A61K 31/41
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 514359, 514374, 514381, 514616, 564153

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7638544, Dec 29, 2009

Filed:

Dec 17, 2007

Appl. No.:

11/958365

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Dallas TX, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/42

US Classification:

514374, 514359, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7816538, Oct 19, 2010

Filed:

Jul 24, 2009

Appl. No.:

12/509190

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
C07D 257/04
A61K 31/41
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 564153, 514359, 514374, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7884211, Feb 8, 2011

Filed:

Jul 24, 2009

Appl. No.:

12/509218

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 514359, 514374, 514381, 514616, 564153

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

8143418, Mar 27, 2012

Filed:

Feb 7, 2011

Appl. No.:

13/022033

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 564153, 514359, 514374, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

8236703, Aug 7, 2012

Filed:

Sep 11, 2008

Appl. No.:

12/208608

Inventors:

Lisa A. Fritz - Dallas TX, US
Lin Li - Plano TX, US
Lee Alan Stringer - Frisco TX, US
Neel A. Bhatt - Allen TX, US
John Paul Campbell - Dallas TX, US
Stephen Arlon Meisner - Allen TX, US
Charles Leighton - Carrollton TX, US

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

H01L 21/302

US Classification:

438754, 438612, 438613, 438614, 438634, 216 37, 216 67

Abstract:

Methods for removing contaminants from a semiconductor device that includes a plurality of aluminum-comprising bond pads on a semiconductor surface of a substrate. A plurality of aluminum-including bond pads are formed on the semiconductor surface of the substrate. A patterned passivation layer is then formed on the semiconductor surface, wherein the patterned passivation layer provides an exposed area for the plurality of bond pads. Wet etching with a basic etch solution is used to etch a surface of the exposed area of the aluminum-including bond pads, wherein the wet etching removes at least 100 Angstroms from the surface of the bond pads to form a cleaned surface.