Lin J Li

US Patent:

7309792, Dec 18, 2007

Filed:

Mar 1, 2005

Appl. No.:

11/070733

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Dallas TX, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
C07D 257/04
A61K 31/41
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 514359, 514374, 514381, 514616, 564153

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7638544, Dec 29, 2009

Filed:

Dec 17, 2007

Appl. No.:

11/958365

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Dallas TX, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/42

US Classification:

514374, 514359, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7816538, Oct 19, 2010

Filed:

Jul 24, 2009

Appl. No.:

12/509190

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
C07D 257/04
A61K 31/41
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 564153, 514359, 514374, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

7884211, Feb 8, 2011

Filed:

Jul 24, 2009

Appl. No.:

12/509218

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 514359, 514374, 514381, 514616, 564153

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

8143418, Mar 27, 2012

Filed:

Feb 7, 2011

Appl. No.:

13/022033

Inventors:

Patrick G. Harran - Dallas TX, US
Xiaodong Wang - Dallas TX, US
Jef K. De Brabander - Dallas TX, US
Lin Li - Dallas TX, US
Ranny Mathew Thomas - Waltham MA, US
Hidetaka Suzuki - Dallas TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 249/04
A61K 31/42

US Classification:

548237, 548251, 548252, 548253, 548255, 564153, 514359, 514374, 514381, 514616

Abstract:

Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

US Patent:

8236703, Aug 7, 2012

Filed:

Sep 11, 2008

Appl. No.:

12/208608

Inventors:

Lisa A. Fritz - Dallas TX, US
Lin Li - Plano TX, US
Lee Alan Stringer - Frisco TX, US
Neel A. Bhatt - Allen TX, US
John Paul Campbell - Dallas TX, US
Stephen Arlon Meisner - Allen TX, US
Charles Leighton - Carrollton TX, US

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

H01L 21/302

US Classification:

438754, 438612, 438613, 438614, 438634, 216 37, 216 67

Abstract:

Methods for removing contaminants from a semiconductor device that includes a plurality of aluminum-comprising bond pads on a semiconductor surface of a substrate. A plurality of aluminum-including bond pads are formed on the semiconductor surface of the substrate. A patterned passivation layer is then formed on the semiconductor surface, wherein the patterned passivation layer provides an exposed area for the plurality of bond pads. Wet etching with a basic etch solution is used to etch a surface of the exposed area of the aluminum-including bond pads, wherein the wet etching removes at least 100 Angstroms from the surface of the bond pads to form a cleaned surface.

US Patent:

20230046337, Feb 16, 2023

Filed:

Aug 13, 2021

Appl. No.:

17/402328

Inventors:

- Cupertino CA, US
Saurabh ADYA - San Jose CA, US
Shruti BHARGAVA - Sunnyvale CA, US
Myra LUKENS - Mountain View CA, US
Jianpeng CHENG - Shanghai, CN
Lin LI - Sunnyvale CA, US
Alkeshkumar PATEL - San Jose CA, US
Dhivya PIRAVIPERUMAL - Sunnyvale CA, US
Stephen Guy PULMAN - Oxfordshire, GB

International Classification:

G10L 15/22
G06F 3/01
G10L 15/18

Abstract:

Systems and processes for operating a digital assistant are provided. An example process for performing a task includes, at an electronic device having one or more processors and memory, receiving a spoken input including a request, receiving an image input including a plurality of objects, selecting a reference resolution module of a plurality of reference resolution modules based on the request and the image input, determining, with the selected reference resolution module, whether the request references a first object of the plurality of objects based on at least the spoken input, and in accordance with a determination that the request references the first object of the plurality of objects, determining a response to the request including information about the first object.

US Patent:

20200104362, Apr 2, 2020

Filed:

Dec 21, 2018

Appl. No.:

16/230342

Inventors:

- Cupertino CA, US
Deepak MURALIDHARAN - Cupertino CA, US
Justine KAO - Millbrae CA, US
Lin LI - San Jose CA, US
Mubarak Ali SEYED IBRAHIM - San Jose CA, US
John G. KEESLING - San Jose CA, US
AtishKumar KOTHARI - Sunnyvale CA, US
Yingjie ZHENG - Sunnyvale CA, US

International Classification:

G06F 17/27
G10L 15/22
G06N 20/00
G06F 16/909

Abstract:

Systems and processes for processing natural language input are described. An example process for processing natural language input includes receiving a natural language input and determining a domain corresponding to the natural language input. The example process further includes, in accordance with determining the domain corresponding to the natural language input, determining, based on the natural language input, a first value for a first property of the domain and determining, based on a named entity model and the natural language input, a second value for the first property of the domain, where the second value defines a parameter for a task corresponding to the natural language input. The example process further includes performing the task based on the parameter and providing a result based on the performed task.