Lin Mei Li

US Patent:

20220280568, Sep 8, 2022

Filed:

Aug 13, 2020

Appl. No.:

17/632869

Inventors:

- Duarte CA, US
Maciej KUJAWSKI - Duarte CA, US
Lin LI - Duarte CA, US
Paul J. YAZAKI - Duarte CA, US

International Classification:

A61K 35/17
C07K 16/28
C07K 16/30
A61K 47/68
A61K 51/10

Abstract:

Provided herein, inter alia, are methods of using bispecific antibody compounds which may bind immune cells and are, inter alia, useful for treating cancers. Anti-tumor antigen antibodies are connected to anti-immune antibodies through their hinge regions using, for example, click chemistry to form dual-specific, bivalent BiTES with high in vivo tumor targeting ability and tumor cytotoxicity.

US Patent:

20230001027, Jan 5, 2023

Filed:

Sep 30, 2020

Appl. No.:

17/764708

Inventors:

- Duarte CA, US
Michael R. Weist - Santa Ana CA, US
Bradley J. Ahrens - San Diego CA, US
Lin Li - Monrovia CA, US
Weidong Hu - Diamond Bar CA, US

International Classification:

A61K 51/04

Abstract:

Provided herein, inter alia, are methods and compositions for detection of vascular calcification.

US Patent:

20210330804, Oct 28, 2021

Filed:

Feb 24, 2021

Appl. No.:

17/184237

Inventors:

- Duarte CA, US
Hua YU - Glendora CA, US
Piotr Marek SWIDERSKI - San Dimas CA, US
John Ernest SHIVELY - Arcadia CA, US
Lin LI - Monrovia CA, US

International Classification:

A61K 47/68
C07K 16/08
C07K 16/18
C07K 16/40
A61K 47/54
A61K 39/44

Abstract:

Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.

US Patent:

20190167116, Jun 6, 2019

Filed:

Nov 15, 2018

Appl. No.:

16/192229

Inventors:

Yu Chen - College Park MD, US
Qinggong Tang - College Park MD, US
Udayakumar Kanniyappan - Hyattsville MD, US
Lin Z. Li - Aston PA, US
He Xu - Lansdowne PA, US
Yi Liu - College Park MD, US
Emily Conant - Philadelphia PA, US

International Classification:

A61B 5/00
A61B 1/07
A61B 1/04
A61B 1/06
A61B 1/00
A61B 10/02

Abstract:

In accordance with aspects of the present disclosure, an exemplary system includes a hollow probe having a lumen containing one or more excitation optical fiber(s) and one or more imaging optical fiber(s) where the probe is sized to access a person's body, a first light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of NADH in breast tissue, a second light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of FAD in tissue such as breast tissue, an image capturing device optically coupled to the imaging fiber(s), and a controller configured to control the first light source and the image capturing device to capture NADH fluorescence signals/intensities while the probe is within the person's body and control the second light source and the image capturing device to capture FAD fluorescence signals/intensities while the probe is within the person's body.

US Patent:

20160317671, Nov 3, 2016

Filed:

Feb 29, 2016

Appl. No.:

15/056777

Inventors:

- Duarte CA, US
Hua Yu - Glendora CA, US
Piotr Marek Swiderski - San Dimas CA, US
John Ernest Shively - Arcadia CA, US
Lin Li - Monrovia CA, US

International Classification:

A61K 47/48
C07K 16/08
C07K 16/40
A61K 39/44
C07K 16/18

Abstract:

Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.

US Patent:

20160015838, Jan 21, 2016

Filed:

Mar 8, 2014

Appl. No.:

14/773733

Inventors:

- Los Angeles CA, US
Peter S. CONTI - Pasadena CA, US
Lin LI - Los Angeles CA, US
Zhanhong WU - Los Angeles CA, US
John E. SHIVELY - Los Angeles CA, US
David HORNE - Los Angeles CA, US

Assignee:

University of Southern California USC Stevens - Los Angeles CA

International Classification:

A61K 51/04
C07K 7/64
C07K 7/08
C07C 317/18
A61K 51/08

Abstract:

A thio-selective radioactive labeling agent has the following general formula: