Lin Q Qu

US Patent:

20050031588, Feb 10, 2005

Filed:

Nov 17, 2003

Appl. No.:

10/715729

Inventors:

Jean-Pierre Sommadossi - Cambridge MA, US
Paolo LaColla - Cagliari, IT
David Standring - Milton MA, US
Vadim Bichko - Belmont MA, US
Lin Qu - Medford MA, US

International Classification:

A61K038/21
A61K031/7056

US Classification:

424085700, 514043000

Abstract:

The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT, of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.

US Patent:

20110129813, Jun 2, 2011

Filed:

Oct 28, 2010

Appl. No.:

12/914914

Inventors:

Jean-Pierre Sommadossi - Boston MA, US
Paolo LaColla - Capoterra, IT
David N. Standring - Milton MA, US
Vadim Bichko - San Diego CA, US
Lin Qu - Webster TX, US

International Classification:

C12Q 1/70
C40B 40/06

US Classification:

435 5, 506 16

Abstract:

The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXGXXXT, of domain B of the RNA polymerase region, or is associated with such a mutation; The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.

US Patent:

20160166597, Jun 16, 2016

Filed:

Dec 16, 2015

Appl. No.:

14/972009

Inventors:

- Cambridge MA, US
- Monserrato, IT
David N. STANDRING - Milton MA, US
Vadim BICHKO - San Diego CA, US
Lin QU - Webster TX, US

International Classification:

A61K 31/7072
C12Q 1/70
C12Q 1/18
A61K 38/21

Abstract:

The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.

US Patent:

20140286900, Sep 25, 2014

Filed:

Feb 18, 2014

Appl. No.:

14/183438

Inventors:

- Cambridge MA, US
Paolo LACOLLA - Capoterra, IT
David N. STANDRING - Milton MA, US
Vadim BICHKO - San Diego CA, US
Lin QU - Webster TX, US

Assignee:

Idenix Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/70
C12Q 1/04

US Classification:

424 857

Abstract:

The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.