Lin Wen Su

US Patent:

20210017283, Jan 21, 2021

Filed:

Mar 19, 2019

Appl. No.:

16/982277

Inventors:

- South San Francisco CA, US
- Princeton NJ, US
Paul O. Sheppard - Granite Falls WA, US
Luis Borges - Houston TX, US
Andrew Rankin - Redwood City CA, US
Keith Sadoon Bahjat - Woodside CA, US
Alan J. Korman - Piedmont CA, US
Xiaodi Deng - San Mateo CA, US
Lin Hui Su - Somerville MA, US
Ginger Rakestraw - Somerville MA, US
Jason R. Pinckney - Westborough MA, US
David A. Critton - Pennington NJ, US
Guodong Chen - East Brunswick NJ, US
Richard Y. Huang - Bridgewater NJ, US
Ekaterina G. Deyanova - Lawrenceville NJ, US

Assignee:

Five Prime Therapeutics, Inc. - South San Francisco CA
Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 16/28
C07K 16/46
A61K 38/16

Abstract:

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

US Patent:

20200231687, Jul 23, 2020

Filed:

Jan 21, 2020

Appl. No.:

16/748518

Inventors:

- Princeton NJ, US
Scott Ronald BRODEUR - New Hope PA, US
Ekaterina DEYANOVA - Lawrenceville NJ, US
Richard Yu-Cheng HUANG - Bridgewater NJ, US
Yun WANG - Plainsboro NJ, US
Alfred Robert LANGISH - Feasterville PA, US
Guodong CHEN - East Brunswick NJ, US
Stephen Michael CARL - Howell NJ, US
Hong SHEN - Belle Mead NJ, US
Achal Mukundrao PASHINE - Mahwah NJ, US
Lin Hui SU - Somerville MA, US

Assignee:

Bristol Myers-Squibb Company - Princeton NJ

International Classification:

C07K 16/28
C12N 15/63
A61P 29/00

Abstract:

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

US Patent:

20200055936, Feb 20, 2020

Filed:

Mar 13, 2018

Appl. No.:

16/493712

Inventors:

- South San Francisco CA, US
- Princeton NJ, US
Paul O. Sheppard - Granite Falls WA, US
Luis Borges - Houston TX, US
Andrew Rankin - Redwood City CA, US
Keith Sadoon Bahjat - Woodside CA, US
Alan J. Korman - Piedmont CA, US
Andy X. Deng - Princeton NJ, US
Lin Hui Su - Somerville MA, US
Ginger Rakestraw - Somerville MA, US

Assignee:

Five Prime Therapeutics, Inc. - South San Francisco CA
Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 16/28

Abstract:

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.