Lin Y Yan

US Patent:

D481962, Nov 11, 2003

Filed:

Sep 11, 2002

Appl. No.:

29/167341

Inventors:

Chun Nan Ou - Shenzhen, CN
GaLei Hu - Shenzhen, CN
Lin Yan - Santa Clara CA
TaiPing Zhou - Santa Clara, CN
Yue Qing Zhao - Shenzhen, CN

Assignee:

Hon Hai Precision Ind. Co., Ltd. - Taipei Hsien

International Classification:

1004

US Classification:

D10 75

US Patent:

7276286, Oct 2, 2007

Filed:

Jul 17, 2001

Appl. No.:

09/907551

Inventors:

Robert G. Chapman - Burlingame CA, US
Emanuele Ostuni - Cambridge MA, US
Michael N. Liang - Somerville MA, US
Lin Yan - East Brunswick NJ, US
George M. Whitesides - Newton MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA

International Classification:

B32B 9/04
B32B 15/04
B32B 15/08
B32B 27/34

US Classification:

4284111, 428332, 428336, 428338, 428339, 428457, 428458, 4284744

Abstract:

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

US Patent:

7494714, Feb 24, 2009

Filed:

Jul 9, 2007

Appl. No.:

11/825998

Inventors:

Robert G. Chapman - San Mateo CA, US
Emanuele Ostuni - Flourtown PA, US
Michael N. Liang - London, GB
Lin Yan - Princeton NJ, US
George M. Whitesides - Newton MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA

International Classification:

B32B 9/04

US Classification:

4284111

Abstract:

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.