Chan K. Hwang - Boulder CO Marcus F. Boehm - San Diego CA Beth Ann Badea - San Diego CA Laura J. Dardashti - Santa Anna CA Lin Zhang - San Diego CA Alex M. Nadzan - San Diego CA Richard A. Heyman - Encinitas CA Ranjan Mukherjee - San Diego CA Deepak S. Lala - San Diego CA Luc J. Farmer - La Jolla CA
Assignee:
Ligand Pharmaceuticals Incorporated - San Diego CA
International Classification:
A61K 3119
US Classification:
514569, 514725, 560500
Abstract:
Dimer-selective RXR modulator compounds having agonist, partial agonist and/or antagonist activity in the context of an RXR homodimer and/or RXR heterodimers are provided. Also provided are pharmaceutical compositions incorporating such dimer-selective RXR modulator compounds and methods for their therapeutic use.
High Dose Solid Unit Oral Pharmaceutical Dosage Form Of Amorphous Nelfinavir Mesylate And Process For Making Same
Martin Howard Infeld - Upper Montclair NJ, US Wantanee Phuapradit - Clifton NJ, US Navnit Hargovindas Shah - Clifton NJ, US Lin Zhang - Piscataway NJ, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 9/20
US Classification:
424464, 424451, 424470, 514772, 5147723
Abstract:
A solid unit oral pharmaceutical dosage form of amorphous nelfinavir mesylate is provided comprising amorphous nelfinavir mesylate in an amount of from about 400 mg to about 700 mg calculated as nelfinavir base, and a pharmaceutically acceptable water soluble, non-ionic synthetic block copolymer of ethylene oxide and propylene oxide, the copolymer having a melting point of at least about 45 C. and an HLB value at 25 C. of from about 18 to about 29, wherein the copolymer is present from about 40% to about 65% by weight of the nelfinavir mesylate. A hot melt granulation process for making the dosage form is provided.
2-Aminopurine Analogs Having Hsp90-Inhibiting Activity
Srinivas Rao Kasibhatla - San Diego CA, US Kevin D. Hong - San Diego CA, US Marcus F. Boehm - San Diego CA, US Marco A. Biamonte - San Diego CA, US Lin Zhang - San Diego CA, US
2-Aminopurine analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e. g. , proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.
Srinivas Rao Kasibhatla - San Diego CA, US Kevin Hong - San Diego CA, US Lin Zhang - San Diego CA, US Marco Antonio Biamonte - San Diego CA, US Marcus F. Boehm - San Diego CA, US Jiandong Shi - San Diego CA, US Junhua Fan - San Diego CA, US
Thomas Arrhenius - Del Mar CA, US Mi Chen - San Diego CA, US Jie Fei Cheng - Carlsbad CA, US Yujin Huang - San Diego CA, US Alex Michael Nadzan - Encinitas CA, US Sovouthy Tith - San Diego CA, US Masayuki Haramura - Chiba, JP David Mark Wallace - San Diego CA, US Steve Joel Brown - San Diego CA, US Charles Stanford Harmon - Rancho Santa Fe CA, US Lin Zhang - San Diego CA, US Gary D. Lopaschuk - Edmonton, CA Jason R. Dyck - Sherwood Park, CA
Assignee:
Chugai Seiyaku Kabushiki Kaisha - Tokyo
International Classification:
C07D 233/00 C07D 233/02 A01N 43/50 A61K 31/415
US Classification:
5483001, 514396
Abstract:
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.
Ansamycins Having Improved Pharmacological And Biological Properties
Lin Zhang - San Diego CA, US Jean-Yves Le Brazidec - San Diego CA, US Lawrence C. Fritz - Rancho Santa Fe CA, US Francis J. Burrows - Solana Beach CA, US Marcus F. Boehm - San Diego CA, US Junhua Fan - San Diego CA, US Sean Konrad McHugh - Ingleside IL, US
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
Malonyl-Coa Decarboxylase Inhibitors Useful As Metabolic Modulators
Thomas Arrhenius - Del Mar CA, US Mi Chen - San Diego CA, US Jie Fei Chang - Carlsbad CA, US Yujin Huang - San Diego CA, US Alex Michael Nadzan - Encinitas CA, US Richard Julius Penuliar - San Diego CA, US David Mark Wallace - San Diego CA, US Lin Zhang - San Diego CA, US Gary D. Lopaschuk - Edmonton, CA Jason R. Dyck - Sherwood Park, CA
Assignee:
Chugai Seiyaku Kabushiki Kaisha - Tokyo
International Classification:
C07D 277/00
US Classification:
548190
Abstract:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
Process For Preparing 17-Allyl Amino Geldanamycin (17-Aag) And Other Ansamycins
Lin Zhang - San Diego CA, US Marcus F. Boehm - San Diego CA, US Siead Zegar - Orland Park IL, US
Assignee:
Conforma Therapeutics Corporation - San Diego CA
International Classification:
C07D 225/00 C07D 295/00
US Classification:
540451
Abstract:
Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.
Nov 2013 to 2000 Regulatory Compliance Analyst InternWake Forest University Winston-Salem, NC Sep 2011 to Dec 2013 Research AssociateNovartis Boston, MA Jun 2013 to Aug 2013 Summer Associate ScientistWake Forest University Winston-Salem, NC Sep 2011 to May 2013 Teaching AssistantPeking University
Mar 2010 to Aug 2011 Research Associate
Education:
Wake Forest University Winston-Salem, NC 2014 Master of Science in ChemistryShaanxi Normal University 2010 Bachelor of Science in Chemistry
Skills:
Basic: pH meter, Analytical balance, Pipetting Chromatographic Techniques: Gas Chromatography, High Performance Liquid Chromatography, Ultra Pressure Liquid Chromatography, Liquid Chromatography-Mass Spectrometry Spectroscopic Techniques: Infrared, UV-Visible, Fluorescence, Nuclear Magnetic Resonance
Living Resources Albany, NY Oct 2010 to Feb 2011 ProgrammerHuman Resources Administration of NYC Brooklyn, NY Sep 2009 to Aug 2010 Application DeveloperMATIS New York, NY Jan 2009 to Sep 2009 Helpdesk Support Technician / IT SpecialistOffice of Urban Affairs, the City College New York, NY Nov 2008 to Jan 2009 Web DeveloperShandong University of Science and Technology, Shandong, China
Jul 2004 to Aug 2008 Assistant ProfessorShandong University of Science and Technology, Shandong, China
Apr 2007 to Aug 2007
Education:
The City College of New York, City University of New York New York, NY Aug 2010 Master's in Computer ScienceShandong University of Science and Technology Jun 2004 Bachelor's in Computer Science
Oct 2005 to May 2011 Senior AccountantTotal Tec Systems, Inc. A company of Bell Micro
Aug 1999 to Oct 2005 AccountantSamsung Electronics America, Inc
Feb 1998 to Aug 1999 Staff Accountant
Education:
Long Island University Brooklyn, NY Jan 1998 M.S in AccountancyUniversity of Baltimore Baltimore, MD Jan 1996 to May 1996 M.S in AccountancyMiddlesex County College Edison, NJ Dec 1994 Accountancy
Skills:
SAP, JDE, Quick books, AS 400, Great plains, MS office
Dec 2007 to 2000 Purchasing / sourcing managerBERLITZ LANGUAGES INC
Jan 2005 to 2000 Chinese InstructorW.A.C. LIGHTING INC Garden City, NY Jul 2005 to Dec 2007 Purchasing buyerAMME DESIGNS, INC Malverne, NY Feb 2004 to Jul 2005 Office ManagerTRI-COLOR LAB Malverne, NY Apr 1998 to Jan 2004 Freelance Designer
Education:
Long Island University / C.W. Post Campus Brookville, NY Dec 2004 Bachelors of Fine Art in Graphic Design
Name / Title
Company / Classification
Phones & Addresses
Lin Zhang Legislative Chair
Cambridge Systematics, Inc. Management Consulting Services
100 Cambridgepark Dr # 23, Cambridge, MA 02140
Lin Zhang Quality Assurance
Liquidnet Holdings, Inc. Security Brokers, Dealers, and Flotation Comp...
498 Fashion Ave Fl 15, New York, NY 10018
Lin Zhang President
ANNOVA CHEM, INC Nonclassifiable Establishments
5940 Pacific Mesa Ct SUITE 202, San Diego, CA 92121 6920 Miramar Rd, San Diego, CA 92121 8582020068
Lin Zhang Vice President
OHANA USA CORP Nonclassifiable Establishments
20291 NE 30 Ave BLDG 1 PH 10, Miami, FL 33180 17555 Atl Blvd, Miami, FL 33160 17555 Atlantic Blvd, Miami, FL 33160 1261 Broadway, New York, NY 10001
Lin Zhang Principal
Himark Trading Inc Whol Nondurable Goods
192 Laurel Ave, Livingston, NJ 07039
Lin Zhang Manager
Parkview Heights LLC
Lin Zhang Physician Assistant
The Albert Einstein Hospital General Hospital · Medical Doctor's Office
1825 Eastchester Rd, Bronx, NY 10461
Lin Zhang Gynecology/Obstetrics, Material Fetal Medicine
American Infertility of New York, PC Medical Doctor's Office
Dr. Zhang graduated from the West China Univ of Med Sci, Chengdu City, Sichuan, China in 1983. He works in Sacramento, CA and specializes in Neurology and Neuromuscular Medicine. Dr. Zhang is affiliated with UC Davis Medical Center.
Dr. Zhang graduated from the West China Univ of Med Sci, Chengdu City, Sichuan, China in 1988. He works in Columbus, OH and 1 other location and specializes in Hematology/Oncology. Dr. Zhang is affiliated with Cincinnati VA Medical Center.
West China University Of Medical Sciences (1988) Montefiore Medical Center *Internal Medicine Wake Forest University Baptist Medical Center *Hematology & Oncology