Dr. Zhang graduated from the West China Univ of Med Sci, Chengdu City, Sichuan, China in 1983. He works in Sacramento, CA and specializes in Neurology and Neuromuscular Medicine. Dr. Zhang is affiliated with UC Davis Medical Center.
Dr. Zhang graduated from the West China Univ of Med Sci, Chengdu City, Sichuan, China in 1988. He works in Columbus, OH and 1 other location and specializes in Hematology/Oncology. Dr. Zhang is affiliated with Cincinnati VA Medical Center.
West China University Of Medical Sciences (1988) Montefiore Medical Center *Internal Medicine Wake Forest University Baptist Medical Center *Hematology & Oncology
Us Patents
Oxidized Cis-Terpenone And Its Use As A Chemoprotective And Anti-Malarial Agent
Qibing Zhou - Glen Allen VA, US Ghislaine Mayer - Richmond VA, US Lin Zhang - Richmond VA, US Jennifer K. Stewart - Richmond VA, US
International Classification:
A61K 31/122 C07C 49/00 A61P 31/00
US Classification:
514680, 568326
Abstract:
4,5,6,7,8,8-cis-hexahydro-2-hydroxy-4,8,8-trimethylphenanthren-9,10-dione (OHCT) is a fully oxidized compound based on the 2-hydroxy-cis-terpenone (HCT). Because OHCT is fully oxidized, it is more stable and less likely to damage cells or cell constituents such as DNA. OHCT has antimalarial activity, noncompetitive inhibitory activity against carcinogenic conversion of aflotoxin B1 (AFB1) to exo-AFB1-epoxide thus inihibiting AFB1 induced cellular toxicity, and inhibitory activity against TCDD induced cellular toxicity.