Linda S Chang

US Patent:

20150158949, Jun 11, 2015

Filed:

Jun 12, 2013

Appl. No.:

14/407156

Inventors:

- Gaithersburg MD, US
Yihong Yao - Gaithersburg MD, US
Bing Wang - Gaithersburg MD, US
Lorin Roskos - Gaithersburg MD, US
Linda Chang - Gaithersburg MD, US

Assignee:

Medlmmune, LLC - Gaithersburg MD

International Classification:

C07K 16/28
G06N 7/00
G06F 19/00
C12Q 1/68

Abstract:

The disclosure provides methods for treating a subject having a type I IFN-mediated disease or disorder comprising administration of a fixed does of an anti-interferon alpha receptor antibody. The disclosure also provides methods for suppressing a type I interferon (IFN) gene signature (GS) in a subject. In addition, the disclosure provides methods of prognosing or monitoring disease progression in a subject having a type I IFN-mediated disease or disorder, methods of predicting a dosage regimen, methods of identifying a candidate therapeutic agent, methods of identifying a patient as a candidate for a therapeutic agent, and methods of designating a personalized therapy.