Linda S Robbins

US Patent:

62618385, Jul 17, 2001

Filed:

Nov 13, 1998

Appl. No.:

9/191359

Inventors:

Roger D. Cone - Oregon City OR
Kathleen G. Mountjoy - Portland OR
Linda S. Robbins - Portland OR

Assignee:

Oregon Health Science University - Portland OR

International Classification:

C07K 14705
C12N 510

US Classification:

435325

Abstract:

The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.

US Patent:

59940875, Nov 30, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/475637

Inventors:

Roger D. Cone - Oregon City OR
Kathleen G. Mountjoy - Portland OR
Linda S. Robbins - Portland OR

Assignee:

Oregon Health Sciences University - Portland OR

International Classification:

G01N 33567
G01N 3353
G01N 33574
G01N 3348

US Classification:

435 721

Abstract:

The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.

US Patent:

58375210, Nov 17, 1998

Filed:

Apr 8, 1993

Appl. No.:

8/044812

Inventors:

Roger D. Cone - Oregon City OR
Kathleen G. Mountjoy - Portland OR
Linda S. Robbins - Portland OR

Assignee:

State of Oregon - Portland OR

International Classification:

C07H 2104
C12N 1512

US Classification:

4352401

Abstract:

The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.