Linda C Shackelford

US Patent:

20180171327, Jun 21, 2018

Filed:

Feb 19, 2018

Appl. No.:

15/899069

Inventors:

- Washington DC, US
Linda C. Shackelford - Webster TX, US

Assignee:

United States of America as Represented by the Administrator of the National Aeronautics and Spac - Washington DC

International Classification:

C12N 13/00
A61N 2/02

Abstract:

The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a transmission component operate as a stimulation field generator to provide a predetermined time-varying stimulation field to up-regulate or down-regulate an expression level of human genes. The present invention also provides a wearable apparatus for delivering the time-varying magnetic field to mammalian cells associated with bone formation in a subject. The wearable apparatus contains the stimulation field generator in a housing. The resulted modification on gene regulation of these genes and mammalian cells promotes the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.

US Patent:

20140342428, Nov 20, 2014

Filed:

Jul 29, 2014

Appl. No.:

14/445995

Inventors:

Thomas J. Goodwin - Kemah TX, US
Linda C. Shackelford - Webster TX, US

Assignee:

USA as Represented by the Administrator of the National Aeronautics and Space Administration - Washington DC

International Classification:

C12N 13/00

US Classification:

4351738

Abstract:

The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.