Ling L Chen

US Patent:

7604771, Oct 20, 2009

Filed:

May 5, 2006

Appl. No.:

11/418957

Inventors:

Sun-Ju Song - Orland Park IL, US
Tae H. Lee - Naperville IL, US
Ling Chen - Woodridge IL, US
Stephen E. Dorris - LaGrange Park IL, US
Uthamalingam Balachandran - Hinsdale IL, US

Assignee:

UChicago Argonne, LLC - Chicago IL

International Classification:

B28B 3/00
B01D 53/22

US Classification:

264674, 264676, 96 11

Abstract:

A thermal method of making a hydrogen permeable composition is disclosed. A mixture of metal oxide powder and ceramic oxide powder and optionally a pore former is formed and pressed to form an article. The article is dried at elevated temperatures and then sintered in a reducing atmosphere to provide a dense hydrogen permeable portion near the surface of the sintered mixture. The dense hydrogen permeable portion has a higher initial concentration of metal than the remainder of the sintered mixture and is present in the range of from about 20 to about 80 percent by volume of the dense hydrogen permeable portion.

US Patent:

7655762, Feb 2, 2010

Filed:

Jan 6, 2006

Appl. No.:

11/327844

Inventors:

Gregory M. Landes - The Woodlands TX, US
Kyu Chung - Granger IN, US
Ling Chen - Blue Bell PA, US
Urvi Desai - The Woodlands TX, US
David Reed Powell - Houston TX, US
Seokjoo Hong - The Woodlands TX, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

C07K 16/18

US Classification:

5303881, 5303879

Abstract:

Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

US Patent:

7959716, Jun 14, 2011

Filed:

Sep 30, 2009

Appl. No.:

12/586978

Inventors:

Sun-Ju Song - Orland Park IL, US
Tae H. Lee - Naperville IL, US
Ling Chen - Woodridge IL, US
Stephen E. Dorris - LaGrange Park IL, US
Uthamalingam Balachandran - Hinsdale IL, US

Assignee:

UChicago Argonne, LLC - Chicago IL

International Classification:

B01D 53/22
C04B 35/64

US Classification:

96 11, 96 7, 95 55, 95 56, 429411, 502 4, 264 44, 264666, 264674, 264676, 264681

Abstract:

A hydrogen permeable membrane is disclosed. The membrane is prepared by forming a mixture of metal oxide powder and ceramic oxide powder and a pore former into an article. The article is dried at elevated temperatures and then sintered in a reducing atmosphere to provide a dense hydrogen permeable portion near the surface of the sintered mixture. The dense hydrogen permeable portion has a higher initial concentration of metal than the remainder of the sintered mixture and is present in the range of from about 20 to about 80 percent by volume of the dense hydrogen permeable portion.

US Patent:

8092796, Jan 10, 2012

Filed:

Dec 4, 2009

Appl. No.:

12/631598

Inventors:

Gregory M. Landes - The Woodlands TX, US
Kyu Chung - Granger IN, US
Ling Chen - Blue Bell PA, US
Urvi Desai - The Woodlands TX, US
David Reed Powell - Houston TX, US
Seokjoo Hong - The Woodlands TX, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

C07K 16/18
A61K 39/395

US Classification:

4241301, 5303879, 5303881, 4241391, 4241411, 4241421, 4241331

Abstract:

Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

US Patent:

8591891, Nov 26, 2013

Filed:

Dec 8, 2011

Appl. No.:

13/315027

Inventors:

Gregory M. Landes - The Woodlands TX, US
Kyu Chung - Granger IN, US
Ling Chen - Blue Bell PA, US
Urvi Desai - The Woodlands TX, US
David Reed Powell - Houston TX, US
Seokjoo Hong - The Woodlands TX, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

A61K 39/395
C07K 16/18

US Classification:

4241301, 4241391, 4241411, 4241421, 4241331, 5303879, 5303881

Abstract:

Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

US Patent:

20050058649, Mar 17, 2005

Filed:

Dec 2, 2003

Appl. No.:

10/726332

Inventors:

Gregory Landes - The Woodlands TX, US
Mary Haak-Frendscho - Newark CA, US
Ling Chen - The Woodlands TX, US
Meina Liang - Danville CA, US
Xiao Feng - Union City CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mark Nocerini - San Francisco CA, US

International Classification:

A61K039/395
C07K016/40

US Classification:

424146100, 530388260

Abstract:

The invention described herein relates to antibodies directed to the antigen phospholipase A2 (PLA2) and uses of such antibodies. In particular, in accordance with some embodiments of the invention, there are provided fully human monoclonal antibodies directed to the antigen PLA2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

US Patent:

20070044662, Mar 1, 2007

Filed:

May 5, 2006

Appl. No.:

11/418954

Inventors:

Sun-Ju Song - Orland Park IL, US
Tae Lee - Naperville IL, US
Ling Chen - Woodridge IL, US
Stephen Dorris - LaGrange Park IL, US
Uthamalingam Balachandran - Hinsdale IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

B01D 53/22

US Classification:

096004000

Abstract:

A method of making a hydrogen permeable in which a colloid suspension of metal powder and ceramic oxide powder dispersed in an organic carrier is contacted with a porous ceramic substrate to deposit a thin film of the colloid suspension on the substrate. The film is then dried and sintered to provide a two part membrane adhered to the porous ceramic substrate. The two part membrane has a metal powder part of one or more of Ni, Pd, Pd alloys, Nb, Ta, Zr, V or mixtures thereof, and an oxide part of one or more of yttria stabilized zirconia, shrinkable alumina, suitably doped cerates, titanates, zirconates of barium or strotium or mixtures thereof, wherein the metal powder part is present in the range of from about 20 to about 80 percent by volume of the two-part membrane.

US Patent:

20070044663, Mar 1, 2007

Filed:

May 5, 2006

Appl. No.:

11/418955

Inventors:

Sun-Ju Song - Orland Park IL, US
Tae Lee - Naperville IL, US
Ling Chen - Woodridge IL, US
Stephen Dorris - LaGrange Park IL, US
Uthamalingam Balachandran - Hinsdale IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

B01D 53/22

US Classification:

096011000

Abstract:

A hydrogen permeable composition having a porous ceramic substrate, and a two part membrane adhered thereto. The two part membrane has a metal powder part and a ceramic oxide part, with the metal powder part being Ni, Pd, Pd alloys, Nb, Ta, Zr, V or mixtures thereof. The oxide part is yttria stabilized zirconia, shrinkable alumina, suitably doped cerates, titanate, zirconates of barium or strontium or mixtures thereof, and the hydrogen flux is at least 20 cmper minute-cmat 500 C. in a 100% hydrogen atmosphere. A paste method of forming the composition is disclosed. A method of extracting hydrogen from a gas is also disclosed.