- Princeton NJ, US Vijay T. Ahuja - Princeton NJ, US Guanglin Luo - Newtown PA, US Ling Chen - Doylestown PA, US Prasanna Sivaprakasam - Lawrenceville NJ, US Gene M. Dubowchik - Middlefield CT, US John E. Macor - Washington Crossing PA, US
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds to treat disorders associated with GSK-3.
- Princeton NJ, US Michael G. Yang - Narbeth PA, US Zili Xiao - East Windsor NJ, US Ling Chen - Doylestown PA, US Ryan M. Moslin - Princeton NJ, US John S. Tokarski - Princeton NJ, US David S. Weinstein - San Diego CA, US
Compounds having the following formula I:or a stereoisomer or pharmaceutically-acceptable salt thereof, where R, R, R, R, and Rare as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
- Princeton NJ, US Ling CHEN - Doylestown PA, US Jonathan L. DITTA - Meriden CT, US Carolyn Diane DZIERBA - Middletown CT, US Prasada Rao JALAGAM - Bangalore, IN Guanglin LUO - Madison CT, US John E. MACOR - Washington Crossing PA, US Tarun Kumar MAISHAL - Bangalore, IN Susheel Jethanand Nara - Chembur, Mumbai, IN Ramkumar RAJAMANI - Acton MA, US Ramesh Kumar SISTLA - Bangalore, IN Soodamani THANGAVEL - Hosur, IN
International Classification:
C07D 513/04 A61P 25/16 A61P 25/18 A61P 25/28
Abstract:
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
- Princeton NJ, US Ling Chen - Doylestown PA, US Jonathan L. Ditta - Meriden CT, US Carolyn Diane Dzierba - Middletown CT, US Prasada Rao Jalagam - Bangalore, IN Guanglin Luo - Madison CT, US John E. Macor - Washington Crossing PA, US Tarun Kumar Maishal - Bangalore, IN Susheel Jethanand Nara - Chembur, Mumbai, IN Ramkumar Rajamani - Acton MA, US Ramesh Kumar Sistla - Bangalore, IN Soodamani Thangavel - Hosur, IN
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
- Princeton NJ, US Ling Chen - Doylestown PA, US Carolyn Diane Dzierba - Middletown CT, US Jonathan L. Ditta - Meriden CT, US John E. Macor - Washington Crossing PA, US Joanne J. Bronson - Durham CT, US
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
- Princeton NJ, US Ling Chen - Doylestown PA, US Carolyn Diane Dzierba - Middletown CT, US Jonathan L. Ditta - Meriden CT, US John E. Macor - Washington Crossing PA, US Joanne J. Bronson - Dorham CT, US
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Jun 2011 to Present Consultant/Sales DirectorChina Logics
2010 to Present FounderSeoul National University of Technology New York, NY Jun 2010 to Jun 2011 An international university admissions advisorInterfax New York, NY 2009 to 2010 Business Development ManagercomScore Inc New York, NY 2007 to 2008 International Business Development SpecialistIDG Publishing
2003 to 2004 Reporter and Editor
Education:
DUKE UNIVERSITY Durham, NC 2006 MA in Liberal Studies and Public PolicyRENMIN UNIVERSITY 2003 BA in Journalism and Mass Communication
Ling P Chen MD 2505 Samaritan Dr STE 107, San Jose, CA 95124 4083588852 (phone), 4083588303 (fax)
Education:
Medical School Case Western Reserve University School of Medicine Graduated: 1992
Procedures:
Cesarean Section (C-Section) Cystoscopy D & C Dilation and Curettage Delivery After Previous Caesarean Section Hysterectomy Myomectomy Oophorectomy Ovarian Surgery Tubal Surgery Vaccine Administration Vaginal Delivery Vaginal Repair
Conditions:
Abnormal Vaginal Bleeding Breast Disorders Conditions of Pregnancy and Delivery Endometriosis Female Infertility
Languages:
Chinese English
Description:
Dr. Chen graduated from the Case Western Reserve University School of Medicine in 1992. She works in San Jose, CA and specializes in Obstetrics & Gynecology. Dr. Chen is affiliated with El Camino Hospital Of Los Gatos and Good Samaritan Hospital.
I love our Lord Jesus! I believe and desire that we are a fragrance of Christ, a letter inscribed with the Spirit of the living God, in the tablets of hearts of flesh, known and the read by all men......
Tagline:
Galatians 2:20
Bragging Rights:
If I must boast, I will boast of the things of my weakness...Most gladly therefore I will rather boast in my weaknesses that the power of Christ might tabernacle over me.
Ling Chen
Education:
Virginia Polytechnic Institute and State University - Computer Science
Ling Chen
Ling Chen
Ling Chen
Ling Chen
News
Gates Foundation: 'We need to reinvent the toilet'
Yu-Ling Chen, from the University of Toronto, is trying to make a toilet that will "sanitize feces within 24 hours" so human waste doesn't transmit disease through a community. Chen plans to use a process of dehydration, filtration and smoldering to render the waste harmless.