Ling Hui Huang

US Patent:

20030130493, Jul 10, 2003

Filed:

Aug 26, 2002

Appl. No.:

10/228762

Inventors:

James Bonini - Oakland NJ, US
Ling Huang - Kearny NJ, US
Beth Borowsky - Flemington NJ, US
John Salon - Santa Paula CA, US
Amy Wilson - Woodstock NY, US
Raisa Nagorny - Fair Lawn NJ, US

International Classification:

C07H021/04
C12Q001/68
C07K014/705
C12P021/02
C12N005/06
A61K038/17

US Classification:

536/023500, 530/350000, 514/012000, 435/006000, 435/069100, 435/320100, 435/325000

Abstract:

This invention provides isolated nucleic acids encoding mammalian Edg7 receptors, purified mammalian Edg7 receptors, vectors comprising nucleic acid encoding mammalian Edg7 receptors, cells comprising such vectors, antibodies directed to mammalian Edg7 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian Edg7 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian Edg7 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian Edg7 receptors, methods of isolating mammalian Edg7 receptors, methods of treating an abnormality that is linked to the activity of the mammalian Edg7 receptors, as well as methods of determining binding of compounds to mammalian Edg7 receptors, methods of identifying agonists and antagonists of Edg7 receptors, and agonists and antagonists so identified.