Richard L. Beard - Newport Beach CA, US Tien T. Duong - Irvine CA, US Janet A. Takeuchi - Anaheim CA, US Ling Li - Irvine CA, US Kwok Yin Tsang - Irvine CA, US Xiaoxia Liu - Tustin CA, US Jayasree Vasudevan - Anaheim CA, US Liming Wang - Irvine CA, US Santosh C. Sinha - Irvine CA, US Haiqing Yuan - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K031/35 A61K031/235 A61K031/19
US Classification:
514456, 514532, 514569, 560 56, 562466
Abstract:
Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
Compounds Having Selective Cytochrome P450Rai-1 Or Selective Cytochrome P450Rai-2 Inhibitory Activity And Methods Of Obtaining The Same
Jayasree Vasudevan - Anaheim CA, US Liming Wang - Irvine CA, US Xiaoxia Liu - Tustin CA, US Kwok Yin Tsang - Irvine CA, US Ling Li - Irvine CA, US Janet A. Takeuchi - Anaheim CA, US Thong Vu - Garden Grove CA, US Richard Beard - Newport Beach CA, US Smita Bhat - Irvine CA, US Vidyasagar Vuligonda - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31/135 C07C 62/00 C07C 69/52 C07C 211/16
US Classification:
514654, 562500, 564384
Abstract:
Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
Methods For Treating Retinoid Responsive Disorders Using Selective Inhibitors Of Cyp26A And Cyp26B
Jayasree Vasudevan - Anaheim CA, US Rong Yang - Viejo CA, US Liming Wang - Irvine CA, US Xiaoxia Liu - Nashua NH, US Ling Li - Irvine CA, US Janet Takeuchi - Anaheim CA, US Thong Vu - Garden Grove CA, US Richard Beard - Newport Beach CA, US Smita Bhat - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
Compounds Having Selective Cytochrome P450Rai-1 Or Selective Cytochrome P450Rai-2 Inhibitory Activity And Methods Of Obtaining The Same
Jayasree Vasudevan - Anaheim CA, US Liming Wang - Irvine CA, US Xiaoxia Liu - Tustin CA, US Kwok Yin Tsang - Irvine CA, US Ling Li - Irvine CA, US Janet A. Takeuchi - Anaheim CA, US Thong Vu - Garden Grove CA, US Richard Beard - Newport Beach CA, US Smita Bhat - Irvine CA, US Vidyasagar Vuligonda - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
Janet A. Takeuchi - Anaheim CA, US Ken Chow - Newport Coast CA, US Ling Li - Irvine CA, US Liming Wang - Irvine CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A01N 43/76 A61K 31/42 C07D 413/00 C07D 263/00
US Classification:
514377, 548233
Abstract:
Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both αand αadrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.
Push-To-Talk Features In Wireless Communications Devices And Methods
Marshall L. Brown - Chicago IL, US David S. Brenner - Mundelein IL, US Thaveesak Kraisornsuthasinee - Chicago IL, US Jennifer M. Lee - Chicago IL, US Ling Li - Vernon Hills IL, US Archana Vohra - San Diego CA, US William L. Zuckerman - Skokie IL, US
Assignee:
Motorola Mobility, Inc. - Libertyville IL
International Classification:
H04B 7/00
US Classification:
455518, 455 902, 4554141, 455450, 370296
Abstract:
A wireless communications terminal that communicates in a communications infrastructure and methods therefor including opening a push-to-talk (PTT) contact list application () on the terminal when the terminal is in a dormant state, for example, by depressing a PTT input, and transitioning the terminal from the dormant state to an active state when the PTT contact list application is opened. Other PTT features include among others indicating on the terminal whether PTT contacts in the contact list are available for a PTT session, and indicating which PTT participant is talking.
N-(1-Phenyl-2-Arylethyl)-4,5-Dihydro-2H-Pyrrol-5-Amine Compounds As Subtype Selective Modulators Of Alpha2B Or Alpha2B And Alpha2C Adrenoceptors
Ken Chow - Newport Coast CA, US Janet A. Takeuchi - Anaheim CA, US Ling Li - Irvine CA, US Todd M. Heidelbaugh - Fountain Valley CA, US Phong X. Nguyen - Placentia CA, US Evelyn G. Corpuz - Irvine CA, US Wenkui K Fang - Irvine CA, US Santosh C. Sinha - Ladera Ranch CA, US Michael E. Garst - Newport Beach CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C07C 257/00 A61K 31/155
US Classification:
564244, 514637
Abstract:
The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula.
Biphenyl Oxadiazole Derivatives As Sphingosine-1-Phosphate Receptors Modulators
Janet A. Takeuchi - Anaheim CA, US Ken Chow - Newport Coast CA, US Ling Li - Irvine CA, US
Assignee:
Allergan, Inc - Irvine CA
International Classification:
A61K 31/4245 C07D 271/06
US Classification:
514364, 548131
Abstract:
The present invention relates to novel biphenyl oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
University of Connecticut 2012 M.Sc. in Materials ScienceWuhan University 2005 B.S. in PharmacologyInstitute of Technology Ph.D. in Materials Science and Engineering
2004 to 2009 Senior Technical SpecialistSpiegel Group Inc
2001 to 2004 Application AnalystJeffrey U. Price & Associates
1999 to 2001 Programmer analystUniversity of Illinois at Chicago Chicago, IL 1996 to 1998 Research AssistantBush Travel Service
1988 to 1995 Database Specialist
Education:
University of Illinois at Chicago Chicago, IL 1997 to 1998 Master of Science in Management Information SystemSichuan University 1984 to 1987 Bachelor of Science in Business Computation
Dr. Li graduated from the Shanghai Med Univ, Shanghai First Med Univ, Shanghai, China in 1991. She works in Springfield, MO and specializes in Neurology. Dr. Li is affiliated with Mercy Hospital Springfield.
Forensic Medical Examiners 900 W Baltimore St, Baltimore, MD 21223 4103333250 (phone), 4103333063 (fax)
Education:
Medical School Tongji Med Univ, Wuhan City, Hubei, China Graduated: 1982
Languages:
English
Description:
Dr. Li graduated from the Tongji Med Univ, Wuhan City, Hubei, China in 1982. She works in Baltimore, MD and specializes in Anatomic Pathology & Clinical Pathology. Dr. Li is affiliated with University Of Maryland Medical Center.
Ling LI (1973-1977), Jennifer Dean (1995-1999), Chantal Pauporte (1989-1993), Daniel Grindlinger (1989-1993), David Pardo (1939-1943), Laura Solinger (1978-1982)