Ling Li

US Patent:

20220226342, Jul 21, 2022

Filed:

Jun 29, 2020

Appl. No.:

17/623060

Inventors:

- Baltimore MD, US
Ling Li - Baltimore MD, US

International Classification:

A61K 31/55
A61P 35/00

Abstract:

Described herein are methods for treating liver tumors and cancer in a subject comprising the steps of administering a suppressor of protein translation to a subject in need thereof. Examples of liver cancer include hepatocellular carcinoma (HCC), cholangiocarcinoma, or a combination thereof. Examples of a suppressor of protein translation includes omacetaxine mepusuccinate, and the methods include combinations with other chemotherapeutic agents.

US Patent:

20230074885, Mar 9, 2023

Filed:

Feb 5, 2021

Appl. No.:

17/797053

Inventors:

- Baltimore MD, US
Hai-Quan Mao - Baltimore MD, US
Ling Li - Baltimore MD, US
Yang Zhou - Baltimore MD, US
Zhiyu He - Baltimore MD, US
Kuntao Chen - Philadelphia PA, US

International Classification:

A61K 47/64
A61K 9/51
A61K 47/54
A61K 45/06
A61P 35/00

Abstract:

The presently disclosed subject matter provides nanoparticles comprising bortezomib encapsulated in a non-water-soluble polymer matrix in a form of a bortezomib-tannic acid complex; methods for preparing the nanoparticle; and use of the nanoparticles for treating liver cancer.

US Patent:

20210333265, Oct 28, 2021

Filed:

Feb 1, 2018

Appl. No.:

16/479652

Inventors:

- Baltimore MD, US
Ling Li - Baltimore MD, US

International Classification:

G01N 33/50
G01N 33/574

Abstract:

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient using mini-cancers to develop personalized cancer drug regimes.

US Patent:

20210011305, Jan 14, 2021

Filed:

Jul 10, 2020

Appl. No.:

16/926352

Inventors:

- Plantation FL, US
Victor Kai Liu - Mountain View CA, US
Samarth Bhargava - Saratoga CA, US
Ling Li - Austin TX, US
Sharad D. Bhagat - Austin TX, US
Christophe Peroz - San Francisco CA, US
Jason Donald Mareno - Raleigh NC, US

Assignee:

Magic Leap, Inc. - Plantation FL

International Classification:

G02B 30/52
G02B 27/00

Abstract:

A dynamic eyepiece for projecting an image to an eye of a viewer includes a waveguide layer having an input surface, an output surface opposing the input surface, and a periphery. The waveguide layer is configured to propagate light therein. The dynamic eyepiece also includes a mechanical structure coupled to at least a portion of the periphery of the waveguide layer. The mechanical structure is operable to apply a first mechanical force to the at least a portion of the periphery of the waveguide layer to impose a first surface profile on the output surface of the waveguide layer and apply a second mechanical force to the at least a portion of the periphery of the waveguide layer to impose a second surface profile different from the first surface profile on the output surface of the waveguide layer.

US Patent:

20200345867, Nov 5, 2020

Filed:

Apr 30, 2020

Appl. No.:

16/864130

Inventors:

- Baltimore MD, US
Vivek Kumbhari - Baltimore MD, US
Ling Li - Baltimore MD, US

International Classification:

A61K 48/00
C12N 15/63
A61P 1/18
A61P 1/16

Abstract:

Intrabiliary hydrodynamic injection of nucleic acid for in vivo gene therapy for treatment of liver or pancreas disease and other disorders.

US Patent:

20200197535, Jun 25, 2020

Filed:

Nov 11, 2019

Appl. No.:

16/679445

Inventors:

- BALTIMORE MD, US
LING LI - BALTIMORE MD, US
STEPHEN J. GOULD - BALTIMORE MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 48/00
C12P 1/00
A61K 31/7105
A61K 47/69
G01N 33/574
A61P 25/00
A61K 35/33
A61K 35/13
C12N 15/113
A61K 33/243
C12P 21/00
A61K 9/107
A61K 31/685
A61K 31/704
A61K 33/24
A61K 45/06
C12P 19/34

Abstract:

The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-

US Patent:

20200018743, Jan 16, 2020

Filed:

Sep 26, 2019

Appl. No.:

16/583738

Inventors:

- Baltimore MD, US
Ling Li - Baltimore MD, US

International Classification:

G01N 33/50
G16H 50/30
G16H 50/50
G16H 50/20
G16H 20/10
G16B 40/10

Abstract:

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient using mini-cancers to develop personalized cancer drug regimes.

US Patent:

20180028687, Feb 1, 2018

Filed:

Jan 29, 2016

Appl. No.:

15/545937

Inventors:

- BALTIMORE MD, US
LING LI - BALTIMORE MD, US
STEPHEN J. GOULD - BALTIMORE MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 48/00
A61K 31/704
A61K 33/24
G01N 33/574
A61K 9/107
C12P 19/34
C12P 21/00
A61K 45/06
A61K 31/685

Abstract:

The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. In a specific embodiment, the present invention provides an extracellular vesicle isolated from a cell comprising one or more microRNAs (miRNAs) that have been loaded ex vivo into the vesicle so that the miRNAs are present in a higher concentration than when measured in the same extracellular vesicle isolated directly from the cell. In another embodiment, the present invention provides a method for treating cholangiocarcinoma in a subject comprising the step of administering to the subject a plurality of exosomes comprising miR-195.