Emmanuel Mignot - Palo Alto CA, US Juliette Faraco - Menlo Park CA, US Hua Li - Union City CA, US Ling Lin - Mountain View CA, US Seiji Nishino - Palo Alto CA, US Hiroshi Kadatoni - Hiroshima, JP
International Classification:
C12Q001/68
US Classification:
435006000
Abstract:
The present invention is directed to methods for identification of compounds that affect wakefulness, attention deficit hyperactivity disorder, chronic fatigue syndrome and mood disorders (e.g., depression) through interaction with the hypocretin receptor system. The present invention is also directed to detection of abnormal levels of hypocretin in a subject, as well as detection of an abnormal immune response against hypocretin (orexins) and/or their receptors, where detection of abnormal hypocretin levels or detection of an abnormal immune response is indicative of a sleep disorder, particularly of narcolepsy. The present invention is also directed to a methods relating to the detection of a mutation or polymorphism in the gene encoding the hypocretin receptors, the detection of antibodies disrupting the function of gene encoding hypocretin receptors and hypocretin polypeptides, and the use of hypocretin biological markers in predicting treatment response using compounds interacting with the hypocretin receptor system.
- Mountain View CA, US Ken Soong - Menlo Park CA, US Carrie Zhuqing Peng - San Jose CA, US Lizabeth Li - Mountain View CA, US Ling Lin - San Jose CA, US Joonhyung Lim - San Jose CA, US Xin Fu - Sunnyvale CA, US Seyedehmina Doroud - Millbrae CA, US Huangming Xie - Menlo Park CA, US
International Classification:
G06Q 10/10 G06Q 50/00 G06F 17/30
Abstract:
A system determines an intent of a current user who is interacting with an online social networking system, and requests information from the current user based on the determined intent of the current user. The system then receives the requested information from the current user, and provides a service or information to the current user based on the intent of the current user and the information provided by the current user.
Isbn (Books And Publications)
Gong Jian Fan Rong: Cheng Yu Jing Ji Qu Fa Zhan Si Lu Yan Jiu Bao Gao Mian Xiang Wei Lai De Qi Dian Ce Lue He Xing Dong Ji Hua
Rong Ling Lin (1994-1998), Kimberly Sacco (1991-1995), Justine Cuomo (1996-2000), John Piacenti (1963-1969), Adele Suika (1951-1958), Susan Safronova (1993-1995)
CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy; Alberto K. De la Herrn-Arita, Birgitte Rahbek Kornum, Josh Mahlios, Wei Jiang, Ling Lin, Tieying Hou, Claudia Macaubas, Mali Einen, Giuseppe Plazzi, Catherine Crowe, Evan W. Ne