Lisa Anne Cole

Address:

4052 W 115 St APT 113, Chicago, IL 60655

Phone:

7734348311

VIN:

1C3CCBBB5CN284106

Make:

CHRYSLER

Model:

200

Year:

2012

US Patent:

20220370490, Nov 24, 2022

Filed:

May 20, 2022

Appl. No.:

17/749977

Inventors:

- Evanston IL, US
Ziyin Huang - Evanston IL, US
Lisa Cole - Chicago IL, US
Cassandra Elizabeth Callmann - Evanston IL, US
Shuya Wang - Evanston IL, US

International Classification:

A61K 31/713
A61P 37/04
A61K 9/127

Abstract:

The present disclosure is generally directed to spherical nucleic acids (SNAs) comprising multiple TLR agonists that enable the simultaneous activation of multiple TLR pathways for maximally synergistic immune activation. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) one or more toll-like receptor 3 (TLR3) agonists encapsulated in the nanoparticle core; and (c) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more toll-like receptor 9 (TLR9) agonist oligonucleotides. Methods of using the SNAs are also provided herein.