Lisa Marshall

US Patent:

63132699, Nov 6, 2001

Filed:

Jun 15, 1999

Appl. No.:

9/333593

Inventors:

Keith C. Deen - Glenmore PA
Peter R. Young - Lawrenceville NJ
Lisa A. Marshall - Wyndmoor PA
Amy K. Roshak - East Norriton PA
Kong B. Tan - Philadelphia PA
Alemseged Truneh - West Chester PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07K 14715
C12N 1512

US Classification:

530350

Abstract:

TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e. g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.

US Patent:

54708826, Nov 28, 1995

Filed:

Jun 2, 1994

Appl. No.:

8/252716

Inventors:

James S. Dixon - Malvern PA
Raplh F. Hall - Villanova PA
Lisa A. Marshall - Wyndmoor PA
Floyd H. Chilton - Pilot Mountain NC
Ruth J. Mayer - Wayne PA
James D. Winkler - Fort Washington PA

Assignee:

SmithKline Beecham Corp. - Philadelphia PA

International Classification:

A01N 4728

US Classification:

514596

Abstract:

This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

US Patent:

48452920, Jul 4, 1989

Filed:

Jan 13, 1988

Appl. No.:

7/143776

Inventors:

William H. McGregor - Malvern PA
Lisa A. Marshall - Wayne PA
John H. Musser - Malvern PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07C 9306
C07C 9104
C07C 8728
C07C 9116

US Classification:

564353

Abstract:

There are disclosed compounds of the formula ##STR1## R is --CH. sub. 2 OH or --CO. sub. 2 R. sup. 3 ; R. sup. 1 is hydrogen, lower alkyl, lower alkoxy or hydroxybenzyl; R. sup. 2 is hydroxyloweralkyl or diloweralkoxyalkyl; R. sup. 3 is hydrogen or lower alkyl; R. sup. 4 is alkyl of 10-20 carbons atoms, phenylalkyl of 11-18 carbon atoms or phenoxyalkyl of 11-18 carbon atoms; or n is 1-3; or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.

US Patent:

57806098, Jul 14, 1998

Filed:

Oct 16, 1996

Appl. No.:

8/730771

Inventors:

Lisa A. Marshall - Wyndmoor PA
Amy K. Roshak - East Norriton PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07H 2104
C12N 1563

US Classification:

536 235

Abstract:

Nucleic acid molecules encoding a human B cell surface molecule are provided. Polypeptides and antibodies which bind to these polypeptides are also provided. In addition, methods of detecting mutated forms of the molecule are provided.

US Patent:

47883049, Nov 29, 1988

Filed:

Dec 7, 1987

Appl. No.:

7/129259

Inventors:

Lisa A. Marshall - Wayne PA
Kurt E. Steiner - Devon PA
Guy A. Schiehser - Malvern PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D30348

US Classification:

549549

Abstract:

There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: ##STR1## wherein R. sup. 1 and R. sup. 2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfony. , halo or nitro; R. sup. 3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms; X is ##STR2## A is --CH. sub. 2 --,--O-- or --S--; m is 0-8; n is 0-7, with the proviso that m+n. ltoreq. 8; or a pharmacologically acceptable salt thereof; and also novel compounds of the above formula in which X is ##STR3##.

US Patent:

59122706, Jun 15, 1999

Filed:

Nov 22, 1996

Appl. No.:

8/737650

Inventors:

James Scott Dixon - Malvern PA
Ralph Floyd Hall - Villanova PA
Lisa Ann Marshall - Wyndmoor PA
Floyd H. Chilton - Pilot Mountain NC
Ruth Judik Mayer - Wayne PA
James David Winkler - Fort Washington PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA
The Johns Hopkins University - Baltimore MD

International Classification:

A01N 4728

US Classification:

514576

Abstract:

This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

US Patent:

49333658, Jun 12, 1990

Filed:

Jan 25, 1989

Appl. No.:

7/301937

Inventors:

Lisa A. Marshall - Fort Washington PA
Kurt E. Steiner - Lawrenceville NJ
Guy A. Schiehser - Yardley PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

A61K 31335

US Classification:

514475

Abstract:

There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicated an effective amount of a compound having the formula: ##STR1## wherein R. sup. 1 and R. sup. 2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro; R. sup. 3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms; X is ##STR2## A is --CH. sub. 2 --, --O-- or --S--; m is 0-8; n is 0-7, with the proviso that m+n. ltoreq. 8; or a pharmacologically acceptable salt thereof.

US Patent:

59358351, Aug 10, 1999

Filed:

Oct 1, 1997

Appl. No.:

8/942218

Inventors:

Lisa Marshall - Wyndmoor PA

Assignee:

Smithkline Beecham Corporation - Philadelphia PA

International Classification:

C12N 1554
C12N 912

US Classification:

435194

Abstract:

Human Myt-1 kinase polypeptides and DNA (RNA) encoding such enzyme and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such human Myt-1 kinase in the development of treatments for cancers, such as leukemias, solid tumors and metastases; chronic inflammatory proliferative diseases, such as psoriasis and rheumatoid arthritis; proliferative cardiovascular diseases, such as restenosis; proliferative ocular disorders, such as diabetic retinopathy and macular degeneration; and benign hyperproliferative diseases, such as benign prostatic hypertrophy and hemangiomas, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.