Lisa M Marshall

US Patent:

20090299196, Dec 3, 2009

Filed:

May 20, 2009

Appl. No.:

12/469395

Inventors:

Moungi G. Bawendi - Cambridge MA, US
Jorge M. Ferrer - Cambridge MA, US
W. David Lee - Brookline MA, US
Lisa F. Marshall - Cambridge MA, US
David G. Kirsch - Durham NC, US

International Classification:

A61B 6/00

US Classification:

600478

Abstract:

A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.

US Patent:

20190239750, Aug 8, 2019

Filed:

Apr 15, 2019

Appl. No.:

16/384355

Inventors:

- Cambridge MA, US
W. David Lee - Brookline MA, US
Lisa F. Marshall - Cambridge MA, US
David G. Kirsch - Durham NC, US

International Classification:

A61B 5/00

Abstract:

A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.

US Patent:

20170184533, Jun 29, 2017

Filed:

Dec 2, 2016

Appl. No.:

15/367250

Inventors:

- Cambridge MA, US
Lisa Marshall - Cambridge MA, US
Martina Medkova - Winchester MA, US
Aaron Oppenheimer - Cambridge MA, US

Assignee:

Daktari Diagnostics, Inc. - Cambridge MA

International Classification:

G01N 27/327
G01N 27/416

Abstract:

Methods for determining and/or quantifying one or more analytes in fluids are generally provided. In some embodiments, a method comprises introducing or exposing a plurality of conjugated capture structures and a plurality of metal-containing (e.g., silver) conjugated particles to a fluid comprising the analyte such that the analyte binds with both a capture structure and a metal-containing (e.g., silver) particle to form a bound complex. The bound complex may then be subjected to conditions (e.g., electrochemical conditions) that allow quantification of the analyte based on the amount of metal-containing particles present. The methods described herein may be useful for determining and quantifying relatively low concentrations of analytes present in a patient sample (e.g., a droplet of whole blood).

US Patent:

20150216416, Aug 6, 2015

Filed:

Feb 6, 2015

Appl. No.:

14/616467

Inventors:

- Cambridge MA, US
- Durham NC, US
W. David Lee - Brookline MA, US
Lisa F. Marshall - Cambridge MA, US
David G. Kirsch - Durham NC, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Duke University - Durham NC

International Classification:

A61B 5/00

Abstract:

A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.