Lisa S Wang

US Patent:

6576619, Jun 10, 2003

Filed:

May 24, 1999

Appl. No.:

09/317523

Inventors:

Brent K. Blackburn - Los Altos CA
Chris Melville - Palo Alto CA
Jeff A. Zablocki - Mountain View CA
Venkata P. Palle - Mountain View CA
Elfaith O. Elzein - Freemont CA
Lisa Wang - Burlingame CA

Assignee:

CV Therapeutics, Inc. - Palo Alto CA

International Classification:

A61K 3170

US Classification:

514 46, 536 276, 536 2762

Abstract:

Esters of N -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivatives having the following formula; wherein the compounds are selective adenosine type 1 receptor agonists that are useful for the treatment cardiovascular diseases and central nervous system disorders.

US Patent:

6781000, Aug 24, 2004

Filed:

Jul 19, 1999

Appl. No.:

09/356842

Inventors:

Lisa Wang - Burlingame CA
Robert T. Lum - Palo Alto CA
Steven R. Schow - Redwood City CA
Alison Joly - San Mateo CA
Suresh Kerwar - Westchester NY
Michael M Wick - Chestnut Hill MA

Assignee:

CV Theurapeutics, Inc.

International Classification:

C07D20912

US Classification:

548492, 548493, 548494, 548500

Abstract:

-ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X is Ar or ArâX wherein X is is âC O, or âCH COâ, and wherein Ar is phenyl, substituted phenyl, indole, substituted indoles, and any other heteroaryls; R , and R are each individually selected from the side chains of the known natural -amino acids and unnatural amino acids, hydrogen, 1-10 carbon linear and branched alkyl, 1-10 carbon linear and branched substituted alkyl, aryl, substituted aryl, 1-10 carbon linear, branched substituted aryl, alkoxyaryl, 3-8 carbon cycloalkyl, heterocycle substituted heterocycle, heteroaryl and substituted heteroaryl; X is selected from hydroxide, monoalkylamino, dialkylamino, alkoxide, arylkoxide and wherein X is hydroxide, arylamino, monoalkylamino, dialkylamino, alkoxide, or arylalkoxide; and R is selected from the known natural -amino acids, unnatural amino acids, hydrogen, 1-10 carbon linear and branched alkyl, 1-10 carbon linear and branched substituted alkyl, aryl, substituted aryl, 1-10 carbon linear and branched substituted aryl, alkoxyaryl, 3-8 carbon cycloalkyl, heterocycle, substituted heterocycle, heteroaryl and substituted heteroaryl.

US Patent:

60751509, Jun 13, 2000

Filed:

Jan 26, 1998

Appl. No.:

9/013365

Inventors:

Lisa Wang - Burlingame CA
Robert T. Lum - Palo Alto CA
Steven R. Schow - Redwood City CA
Alison Joly - San Mateo CA
Suresh Kerwar - Westchester NY
Michael M Wick - Chestnut Hill MA

Assignee:

CV Therapeutics, Inc. - Palo Alto CA

International Classification:

C07D20912
A01N 4338

US Classification:

548494

Abstract:

alpha. -ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X. sub. 2 is Ar or Ar--X. sub. 3 wherein X. sub. 3 is --C. dbd. O, or --CH. sub. 2 CO--, and wherein Ar is phenyl, substituted phenyl, indole, substituted indoles, and any other heteroaryls; R. sub. 1, and R. sub. 2 are each individually selected from the side chains of the known natural. alpha. -amino acids and unnatural amino acids, hydrogen, 1-10 carbon linear and branched alkyl, 1-10 carbon linear and branched substituted alkyl, aryl, substituted aryl, 1-10 carbon linear, branched substituted aryl, alkoxyaryl, 3-8 carbon cycloalkyl, heterocycle substituted heterocycle, heteroaryl and substituted heteroaryl; X. sub. 1 is selected from hydroxide, monoalkylamino, dialkylamino, alkoxide, arylkoxide and ##STR1## wherein X. sub. 4 is hydroxide, arylamino, monoalkylamino, dialkylamino, alkoxide, or arylalkoxide; and R. sub.