Long H Nguyen

US Patent:

7939318, May 10, 2011

Filed:

Apr 24, 2006

Appl. No.:

11/410572

Inventors:

Alison A. McCormick - Vacaville CA, US
Mark L. Smith - Davis CA, US
Kenneth E. Palmer - Vacaville CA, US
John A. Lindbo - Vacaville CA, US
Long V. Nguyen - Vacaville CA, US
Gregory P. Pogue - Vacaville CA, US

Assignee:

Kentucky Bioprocessing, LLC - Owensboro KY

International Classification:

C12N 15/63
A61K 35/00

US Classification:

4353201, 424 931

Abstract:

Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

US Patent:

8212392, Jul 3, 2012

Filed:

Dec 19, 2007

Appl. No.:

11/960384

Inventors:

Ariel Pickholz - Even Yehuda, IL
Long Nguyen - Irvine CA, US
Shay Mizrachi - Hod HaSharon, IL

Assignee:

Broadcom Corporation - Irvine CA

International Classification:

H02J 1/10
G06F 1/32

US Classification:

307 38, 307 23, 307 29, 307 39, 713330

Abstract:

Methods and systems for supplying power to multiple voltage islands using a single supply source are disclosed. Aspects of one method may include providing power to a first of a plurality of voltage islands, and individually controlling providing of power to each of a remaining portion of the plurality of voltage islands. For example, when an electronic system is first powered on, a low current voltage source may be used to supply power to a primary voltage island. As a higher current voltage source becomes available, power derived from the higher current voltage source may be provided to the primary voltage island and to secondary voltage islands. Power to each of the secondary voltage islands may be, for example, individually controlled via a power MOS transistor. The power MOS transistor may also be configured to allow a faster blocking time than unblocking time.

US Patent:

20040033585, Feb 19, 2004

Filed:

Jun 6, 2003

Appl. No.:

10/457082

Inventors:

Alison McCormick - Vacaville CA, US
Mark Smith - Davis CA, US
Kenneth Palmer - Vacaville CA, US
John Lindbo - Vacaville CA, US
Long Nguyen - Vacaville CA, US
Gregory Pogue - Vacaville CA, US

International Classification:

C12N015/86
C12N007/00

US Classification:

435/235100, 435/456000

Abstract:

Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

US Patent:

20040106198, Jun 3, 2004

Filed:

Jul 16, 2003

Appl. No.:

10/620669

Inventors:

Kathleen Hanley - Vacaville CA, US
Fakhrieh Vojdani - Davis CA, US
Long Nguyen - Vacaville CA, US
Wayne Fitzmaurice - Vacaville CA, US

Assignee:

LARGE SCALE BIOLOGY CORPORATION - Vacaville CA

International Classification:

C12N005/04

US Classification:

435/419000

Abstract:

The invention provides a system for expressing a foreign peptide in a plant cell, wherein the foreign protein is sensitive to a protease activity in the plant cell, by introducing into a plant cell a polynucleotide, which encodes the foreign protein and an another polynucleotide, which encodes a genetic element capable of reducing the protease activity in the plant cell. The invention also provides for plant cells, which incorporate this system, and for methods of reducing the proteolysis of the foreign protein expressed in a plant cell by using this system.

US Patent:

20040170606, Sep 2, 2004

Filed:

Sep 3, 2003

Appl. No.:

10/654200

Inventors:

Kenneth Palmer - Vacaville CA, US
Long Nguyen - Vacaville CA, US
Rachel Toth - Fife, GB
Michael Jones - Dundee, GB
Sean Chapman - Fife, GB
Lisa Smolenska - Dundee, GB
Alison McCormick - Vacaville CA, US
Gregory Pogue - Vacaville CA, US

International Classification:

A61K048/00
C12N015/86

US Classification:

424/093200, 435/456000

Abstract:

Vaccines and diagnostic composition are made and used for preventing, treating and detecting antigens from a papilloma virus, ebola virus, HIV virus, Rift Valley Fever virus or a parvovirus. The epitopes of these viruses are produced as genetically engineered fusion peptides in plants by infection with a recombinant tobamovirus vectors to express fusion proteins containing the epitope peptides.

US Patent:

20050282263, Dec 22, 2005

Filed:

Mar 25, 2005

Appl. No.:

11/090497

Inventors:

Alison McCormick - Vacaville CA, US
Mark Smith - Davis CA, US
Kenneth Palmer - Vacaville CA, US
John Lindbo - Wooster OH, US
Long Nguyen - Vacaville CA, US
Gregory Pogue - Vacaville CA, US

Assignee:

LARGE SCALE BIOLOGY CORPORATION - Vacaville CA

International Classification:

C12N007/00
C12N015/86

US Classification:

435235100, 435456000

Abstract:

Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into coat proteins or encapsidation intermediate populations. Each population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different coat proteins or encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different coat proteins such that the reassembled VLP displays more than one peptide or other molecule. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.

US Patent:

20090032013, Feb 5, 2009

Filed:

Jul 31, 2007

Appl. No.:

11/888489

Inventors:

Long N. Nguyen - Tustin CA, US

International Classification:

F24B 1/18

US Classification:

126512

Abstract:

A gas fireplace is provided including a first housing having a first upper wall, and a second housing within the first housing having a second upper wall spaced apart from the first upper wall and defining a space there between. A combustion chamber is defined within said second housing. The fireplace further includes an elbow flue for the exhaust of gases generated in the fireplace. The elbow flue is coupled to the second upper wall and extends within the space. The elbow flue is rotatable relative to the upper walls about a vertical axis.

US Patent:

20110139738, Jun 16, 2011

Filed:

Dec 10, 2009

Appl. No.:

12/635070

Inventors:

John L. Raybuck - Irvine CA, US
Long Q. Nguyen - Tustin CA, US

International Classification:

A61G 12/00
A47F 7/00
B23P 11/00

US Classification:

211 8513, 29428

Abstract:

In various embodiments a frame system for a surgical system may include a plurality of rod structures cross connected through one or more structural members. In some embodiments, the rod structures may each include at least one rod with an interface joint molded over the at least one rod. One or more of the interface joints may include a receiving hole for receiving a structural member to couple at least two of the plurality of rod structures together. One or more surgical components (such as a surgical console) may be received into the frame system. Other components may also be received into the frame system (e.g., an aesthetic skin). The rod structures may also include cross face structural members that are secured to portions of the rod structures through being molded to the rod structures through the interface joints.