An objective of the present invention is to provide an anti-graying agent. The present invention provides a method for screening an anti-graying agent whereby a substance that increases expression of AFF-4 in cells is selected by applying a candidate substance to cells in vitro; and, an anti-graying agent containing at least one type of herbal extract selected from the group consisting of (Fr.) Karst. extract, Nees extract, (Rice) Bran extract and extract selected with this method in an amount effective for increasing expression of AFF-4.