Louis Pollard Smith

US Patent:

6344436, Feb 5, 2002

Filed:

Jan 8, 1996

Appl. No.:

08/584043

Inventors:

Louis C. Smith - Houston TX
James T. Sparrow - Houston TX
Jochen Hauer - Houston TX
Martha P. Mims - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C07K 1400

US Classification:

514 2, 530345, 530359, 530402

Abstract:

Peptide-macromolecule complexes for delivery of nucleic acid to a cell. The nucleic acid carrier includes a binding complex. The binding complex contains a binding moiety which noncovalently binds to the nucleic acid. The binding complex can also contain a binding moiety which is associated with a surface ligand, nuclear ligand or a lysis agent. These may be associated with the binding moiety by spacers. In addition, the carrier may include a nucleic acid with a combination of the above binding complexes or binding moieties.

US Patent:

8209006, Jun 26, 2012

Filed:

Sep 8, 2003

Appl. No.:

10/657725

Inventors:

Louis C. Smith - Houston TX, US
Ruxandra Draghia-Akli - Houston TX, US
Amir S. Khan - Houston TX, US
Robert H. Carpenter - Bastrop TX, US
Jeff Darnell - The Woodlands TX, US

Assignee:

VGX Pharmaceuticals, Inc. - Blue Bell PA

International Classification:

A61N 1/30

US Classification:

604 21, 604 20

Abstract:

An electroporation device which may be used to effectively facilitate the introduction of a macromolecule into cells of a selected tissue in a body or plant. The electroporation device comprises an electro-kinetic device (“EKD”) whose operation is specified by software or firmware. The EKD produces a series of programmable constant-current pulse patterns between electrodes in an array based on user control and input of the pulse parameters and allows the storage and acquisition of current waveform data. The electroporation device also comprises a replaceable electrode disk having an array of needle electrodes, a central injection channel for an injection needle, and a removable guide disk.

US Patent:

20020173456, Nov 21, 2002

Filed:

Mar 12, 2001

Appl. No.:

09/805301

Inventors:

Louis Smith - Houston TX, US
James Soarrow - Houston TX, US
Jochen Hauer - Houston TX, US
Martha Mims - Houston TX, US

Assignee:

Baylor College of Medicine

International Classification:

A61K038/16
C07K014/435

US Classification:

514/012000, 530/350000, 514/008000, 530/395000

Abstract:

Peptide-macromolecule complexes for delivery of nucleic acid to a cell. The nucleic acid carrier includes a binding complex. The binding complex contains a binding moiety which noncovalently binds to the nucleic acid. The binding complex can also contain a binding moiety which is associated with a surface ligand, nuclear ligand or a lysis agent. These may be associated with the binding moiety by spacers. In addition, the carrier may include a nucleic acid with a combination of the above binding complexes or binding moieties.

US Patent:

59941090, Nov 30, 1999

Filed:

Jun 3, 1995

Appl. No.:

8/460890

Inventors:

Savio L. C. Woo - Houston TX
Louis C. Smith - Houston TX
Richard J. Cristiano - Pearland TX
Stephen Gottchalk - Houston TX
Jim Sparrow - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1563
C12N 700
C07K 400
C07H 2100

US Classification:

4351723

Abstract:

Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.

US Patent:

52686981, Dec 7, 1993

Filed:

Jul 31, 1992

Appl. No.:

7/923848

Inventors:

Louis P. Smith - Denham Springs LA
Louis P. Smith - Baton Rouge LA
Harry D. Ritch - Bay St. Louis MS

International Classification:

G01S 302
G08B 1318
G06F 1548

US Classification:

342450

Abstract:

In accordance with the present invention there is provided a monitoring system that monitors and locates objects such as airplanes and other vehicles on runways, taxiways, or other preprogrammed areas. The invention utilizes a minimum of three transmitters for generating a diffusion field and two receivers which detect displacements in a diffusion field. The receivers are coupled with a computer which calculates the position of the object causing the displacement in the diffusion field. The area to be monitored is divided into grids which are programmed onto the computer, and objects moving in the monitored area cause changes in the signal received by the receivers which are conveyed to the computer and compared by the computer to the programmed grid to indicate the location of the object causing the changes.

US Patent:

60338849, Mar 7, 2000

Filed:

Dec 14, 1993

Appl. No.:

8/167641

Inventors:

Savio L. C. Woo - Houston TX
Louis C. Smith - Houston TX
Richard J. Cristiano - Pearland TX
Stephen Gottchalk - Houston TX
Jim Sparrow - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1500
C12Q 168

US Classification:

4351723

Abstract:

Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.

US Patent:

61775541, Jan 23, 2001

Filed:

Jun 5, 1995

Appl. No.:

8/462040

Inventors:

Savio L. C. Woo - Houston TX
Louis C. Smith - Houston TX
Richard J. Cristiano - Pearland TX
Stephen Gottchalk - Houston TX
Jim Sparrow - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C07H 2102
C07H 2104
C07H 1900
C07H 2100

US Classification:

536 231

Abstract:

Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.

US Patent:

61501689, Nov 21, 2000

Filed:

Jun 5, 1995

Appl. No.:

8/460971

Inventors:

Savio L. C. Woo - Houston TX
Louis C. Smith - Houston TX
Richard J. Cristiano - Pearland TX
Stephen Gottchalk - Houston TX
Jim Sparrow - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1500
C12N 1511
C12Q 168
C12P 1934

US Classification:

435440

Abstract:

Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.