Louise A Williams

US Patent:

20130096009, Apr 18, 2013

Filed:

Sep 22, 2009

Appl. No.:

13/121158

Inventors:

Job Dekker - Princeton MA, US
Erez Lieberman - Cambridge MA, US
Nynke Van Berkum - NW Den Haag, NL
Andreas Gnirke - Wellesley MA, US
Eric Lander - Cambridge MA, US
Chad Nusbaum - Nowtoa MA, US
Louise Williams - Reading MA, US
Alexandre Melnikov - Bellingham MA, US
Georgia Giannoukos - Cambridge MA, US

Assignee:

University of Massachusetts - Boston MA
Whitehead Institute for Biomedical Research - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

506 2, 506 9, 506 33

Abstract:

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

US Patent:

20210040547, Feb 11, 2021

Filed:

Aug 11, 2020

Appl. No.:

16/990543

Inventors:

- Boston MA, US
- Cambridge MA, US
Eric Lander - Cambridge MA, US
Chad Nusbaum - Newton MA, US
Louise Williams - Reading MA, US
Alexandre Melnikov - Bellingham MA, US
Georgia Giannoukos - Cambridge MA, US

International Classification:

C12Q 1/6837
C12Q 1/68

Abstract:

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

US Patent:

20170369937, Dec 28, 2017

Filed:

Jun 15, 2017

Appl. No.:

15/624077

Inventors:

- Boston MA, US
- Cambridge MA, US
Eric Lander - Cambridge MA, US
Chad Nusbaum - Newton MA, US
Louise Williams - Reading MA, US
Alexandre Melnikov - Bellingham MA, US
Georgia Giannoukos - Cambridge MA, US

International Classification:

C12Q 1/68

Abstract:

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

US Patent:

20160312273, Oct 27, 2016

Filed:

Apr 25, 2016

Appl. No.:

15/137988

Inventors:

- Boston MA, US
- Cambridge MA, US
Eric Lander - Cambridge MA, US
Chad Nusbaum - Newton MA, US
Louise Williams - Reading MA, US
Alexandre Melnikov - Bellingham MA, US
Georgia Giannoukos - Cambridge MA, US

International Classification:

C12Q 1/68

Abstract:

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

US Patent:

20140228223, Aug 14, 2014

Filed:

May 10, 2011

Appl. No.:

13/697108

Inventors:

Andreas Gnirke - Wellesley MA, US
Robert Nicol - Cambridge MA, US
Louise Williams - Reading MA, US
Maura T. Costello - Malden MA, US
Scott Steelman - Woburn MA, US

International Classification:

C12Q 1/68

US Classification:

506 2, 4353201, 506 26, 506 14

Abstract:

The present invention is related to genomic nucleotide sequencing. In particular, the invention describes a paired end sequencing method that improves the yield of long-distance genomic read pairs by constructing long-insert clone libraries (i.e., for example, a fosIll library or a fosCN library) and converting the long-insert clone library using inverse polymerase chain reaction amplification or shearing and recircularization of shortened fragments into a library of co-ligated clone-insert ends. The resultant jumping libraries are compatible with massively parallel sequencing techniques. The compositions and methods disclosed herein contemplate sequencing complex genomes as well as detecting chromosomal structural rearrangements.