Lu L Li

US Patent:

20110184684, Jul 28, 2011

Filed:

Mar 7, 2011

Appl. No.:

13/041990

Inventors:

Lu Li - Sunnyvale CA, US
Animesh Khemka - San Jose CA, US

Assignee:

EIGEN, INC. - Grass Valley CA

International Classification:

G06F 19/00

US Classification:

702 94

Abstract:

This application presents a new system and method for image acquisition of internal human tissue, including but not limited to the prostate, as well as a system and method for the guidance and positioning of medical devices relative to the internal tissue. In the presented systems and methods, ultrasound scanned data (e.g., 2-D B-mode images) are acquired freehand absent a mechanical armature that constrains an ultrasound acquisition probe in a known spatial framework. To allow for reconstruction of the scanned data into a 3-D image, multiple tracker sensors that provide position/location information are used with a freehand acquisition probe (e.g., handheld ultrasound probe). The position of such tracker sensors can be calculated when disposed in an electromagnetic field.

US Patent:

20190201214, Jul 4, 2019

Filed:

Mar 11, 2019

Appl. No.:

16/298086

Inventors:

- Fremont CA, US
Rose A. Cipriano - Fremont CA, US
Lu Li - Fremont CA, US

International Classification:

A61F 2/46
A61F 2/30
A61B 34/10
A61B 17/17

Abstract:

Methods, devices and systems for the planning and execution of computer-assisted robotic surgery are provided. The methods include methods to collect information about bones and prostheses, use the information to create virtual models and simulations, optionally receive input based on user discretion in generating the cut file, and to generate instruction for the execution of cut paths during the surgery. The system and devices include computers and peripherals and set-ups to link the components together into functional systems.

US Patent:

20180055944, Mar 1, 2018

Filed:

Aug 1, 2017

Appl. No.:

15/666515

Inventors:

- Camarillo CA, US
Jian-Feng Lu - Oak Park CA, US
Lan Yang - Camarillo CA, US
Lu Li - Camarillo CA, US
Lei Liu - Thousand Oaks CA, US
Shiwen Zhang - Camarillo CA, US

Assignee:

AskGene Pharma Inc. - Camarillo CA

International Classification:

A61K 47/64
A61K 47/68
C07K 16/30
C07K 14/765
A61K 38/07

Abstract:

The present invention relates to compositions and methods using an isolated chimeric molecule, wherein the isolated chimeric molecule comprises an antibody, one or more albumin motifs, optional peptide linkers, and two or more antibiotics or cytotoxic drug molecules conjugated to the unpaired cysteine residues, optionally through linkers. In one embodiment, each of the said albumin motifs in the isolated chimeric molecule contains 2 or more unpaired cysteine residues. In another embodiment, the said antibody in the isolated chimeric molecule targets antigens on cancer cells or drug-resistant bacteria. In another embodiment, the cancer cells have upregulated macropinocytosis. In another embodiment, the cancer cells contain one or more mutations in their RAS family genes. The compositions of the invention are used to treat drug-resistant bacterial infections and cancers, preferably the ones with upregulated macropinocytosis, and the ones containing one or more mutations in their RAS family genes.

US Patent:

20180009869, Jan 11, 2018

Filed:

Jul 8, 2017

Appl. No.:

15/644764

Inventors:

- Camarillo CA, US
Jianfeng Lu - Oak Park CA, US
Lan Yang - Camarillo CA, US
Lu Li - Camarillo CA, US
Kurt SHANEBECK - Camarillo CA, US
Lei Liu - Thousand Oaks CA, US

Assignee:

AskGene Pharma, Inc. - Camarillo CA

International Classification:

C07K 14/575
C07K 7/08
C07K 14/76
A61K 38/00

Abstract:

The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo. The present invention also provides human, canine and feline leptin molecules fused to peptides, antibodies or antibody fragments which enhances the abilities of the leptin molecules to transport through the blood-brain-barrier (BBB). The present invention also provides fusion proteins further comprising a peptide agonist that is capable of binding to and stimulate one, two or all three of the following receptors: GLP-1 receptor, Glucagon receptor, and GIP receptor. Also disclosed is a method of production such fusion proteins through recombinant technologies. The invention further discloses a pharmaceutical composition comprising one of the fusion proteins as an active intergradient as well as a method for using such a pharmaceutical composition to treat diseases in dogs, cats and humans.

US Patent:

20160038243, Feb 11, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/417446

Inventors:

Denise A. Miller - Fremont CA, US
Rose A. Cipriano - Fremont CA, US
Lu Li - Fremont CA, US

International Classification:

A61B 19/00
A61B 17/17
A61F 2/30
A61F 2/46

Abstract:

Methods, devices and systems for the planning and execution of computer-assisted robotic surgery are provided. The methods include methods to collect information about bones and prostheses, use the information to create virtual models and simulations, optionally receive input based on user discretion in generating the cut file, and to generate instruction for the execution of cut paths during the surgery. The system and devices include computers and peripherals and set-ups to link the components together into functional systems.