Lu I Li

US Patent:

20190012425, Jan 10, 2019

Filed:

Jul 18, 2018

Appl. No.:

16/038565

Inventors:

- Fremont CA, US
In K. Mun - Nanuet NY, US
Lu Li - Sunnyvale CA, US

International Classification:

G06F 19/12
G06T 17/00
A61B 34/10
A61B 17/15
A61B 6/00
A61B 6/03
A61B 90/00
A61B 34/20
A61B 17/00

Abstract:

Described herein are systems and methods for creating a custom registration guide. In general, the methods may include receiving scan data of a patient's bone; creating instructions based on the scan data for creating a three-dimensional surface model of the patient's bone; and moving a plurality of moveable elements, coupled to the adjustable model, based on the instructions. The method may further include the steps of placing a malleable registration guide onto the adjustable model and shaping the registration guide to fit to the adjustable model. The method may further include the step of intraoperatively determining the location of a patient's bone using the custom registration guide. The step of determining the location of the patient's bone may include the steps of coupling the registration guide and fiducial markers to the patient's bone.

US Patent:

20160184029, Jun 30, 2016

Filed:

Dec 30, 2015

Appl. No.:

14/984236

Inventors:

- Seattle WA, US
Brian Russell Long - Seattle WA, US
Lu Li - Bellevue WA, US

International Classification:

A61B 34/20
A61B 5/04
A61B 5/00
A61B 34/10

Abstract:

Systems and methods to facilitate automated image-guided experiments including in vivo electrophysiology and electroporation are disclosed. Exemplary systems and methods utilize three-dimensional image data to estimate coordinates of target cells and calculate a path for a probe to carry out an initial approaching toward a target location. Visualization and real-time image analysis is then employed to modify the path based on updated three-dimensional data of the probe location and target location, compensating displacement of target location due to the insertion of the probe into the tissue. Precise control of the probe then performs final approaching of the probe to the target location. This adaptive pipette positioning technique provides a platform for future advances in automated in vivo experiments.