Ludmila Belayev - Miami FL, US Myron Ginsburg - Coconut Grove FL, US
International Classification:
A61K031/551 A61K031/724
US Classification:
514/220000, 514/058000
Abstract:
The invention provides compositions and methods for treating traumatic brain injury by the administration of a noncompetitive AMPA receptor antagonist. In certain embodiments, the noncompetitive AMPA receptor antagonist is a 2,3-benzodiazepine derivative. Illustrative 2,3-benzodiazepine derivatives useful according to the invention include (R)-7-acetyl-5(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine.