Luping Te Wu

US Patent:

20070077657, Apr 5, 2007

Filed:

Mar 24, 2006

Appl. No.:

11/389621

Inventors:

Eric Carlson - Cupertino CA, US
Peijun Cong - San Jose CA, US
William Chandler - Milpitas CA, US
Henry Chau - Sunnyvale CA, US
Earl Danielson - Santa Barbara CA, US
Peter Desrosiers - Santa Clara CA, US
Robert Doolen - Sunnyvale CA, US
Luping Wu - Sunnyvale CA, US
C. Ramberg - San Jose CA, US
Thomas Crevier - Sunnyvale CA, US
Ralph Nielsen - McClean VA, US
Colin Masui - Santa Clara CA, US
John Varni - Los Gatos CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 31/00

US Classification:

436004000

Abstract:

The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

US Patent:

20090046535, Feb 19, 2009

Filed:

Jul 25, 2008

Appl. No.:

12/180001

Inventors:

Eric D. Carlson - Cupertino CA, US
Dave Huffman - Livermore CA, US
Grant Gavranovic - Palo Alto CA, US
Stephen Mark Lambert - Castro Valley CA, US
Luping Wu - Sunnyvale CA, US

International Classification:

B01F 11/04

US Classification:

366118, 901 2

Abstract:

A system for mixing powdered materials includes a cannula and an actuator adapted to vibrate the cannula. An optional fluid delivery system is operable to add fluid to the powdered mixture through the cannula. The cannula can be extended into a powder bed and vibrated by the actuator to mix the powder bed. Fluid can be added to the powder bed through the cannula. The systems and methods are suitable for preparing relatively small quantities of candidate mixtures for high-throughput screening. Sample mixtures prepared by the mixing system can be pressed into tablets that are substantially devoid of foreign objects used to mix the samples. The sample mixtures can be subjected to one or more tests, such as an accelerated aging or forced degradation test, to assess one or more characteristics of the sample mixtures.

US Patent:

20030124028, Jul 3, 2003

Filed:

May 24, 2002

Appl. No.:

10/156222

Inventors:

Eric Carlson - Cupertino CA, US
Peijun Cong - San Jose CA, US
William Chandler - Milpitas CA, US
Henry Chau - Sunnyvale CA, US
Earl Danielson - Santa Barbara CA, US
Peter Desrosiers - Santa Clara CA, US
Robert Doolen - Sunnyvale CA, US
Luping Wu - Sunnyvale CA, US
C. Ramberg - San Jose CA, US
Thomas Crevier - San Jose CA, US
Ralph Nielsen - San Jose CA, US
Colin Masui - Santa Clara CA, US
John Varni - Los Gatos CA, US

International Classification:

G01N021/47
G01N033/00

US Classification:

422/068100, 422/082050

Abstract:

The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.