Lynn C Winterton

US Patent:

6451871, Sep 17, 2002

Filed:

Apr 27, 2000

Appl. No.:

09/559945

Inventors:

Lynn Cook Winterton - Alpharetta GA
Juergen Vogt - Fribourg, CH
John Martin Lally - Lilburn GA
Friedrich Stockinger - Courtepin, CH

Assignee:

Novartis AG - Basel

International Classification:

G02C 704

US Classification:

523106, 264 132, 427 224, 427162, 523105, 523107, 523108, 623 611

Abstract:

Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.

US Patent:

6589665, Jul 8, 2003

Filed:

May 30, 2001

Appl. No.:

09/867827

Inventors:

Peter Chabrecek - Riehen, CH
Dieter Lohmann - Münchenstein, CH
Jörg Leukel - Freiburg, DE
Lynn Cook Winterton - Alpharetta GA
Yongxing Qiu - Dunwoody GA
John Martin Lally - Lilburn GA

Assignee:

Novartis AG - Basel

International Classification:

G02B 104

US Classification:

428520, 427 224, 427508, 428500, 428515, 428522

Abstract:

The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having attached to its surface at least one polyionic material that comprises covalently bound initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic monomers or macromonomers to the bulk material surface provided with the initiator radicals and polymerizing said monomers or macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

US Patent:

6719929, Apr 13, 2004

Filed:

Jan 31, 2001

Appl. No.:

09/774942

Inventors:

Lynn Cook Winterton - Alpharetta GA
Yongxing Qiu - Duluth GA
John Martin Lally - Lilburn GA
Paul Clement Nicolson - Dunwoody GA

Assignee:

Novartis AG - Basel

International Classification:

B29D 1100

US Classification:

264 17, 264 138, 264255

Abstract:

A method of forming a contact lens within a mold is provided. A coating of a polyionic material(s) is applied to the mold before forming a lens therein. The coating can be applied by spraying or dipping the mold within a solution(s) of polyionic materials. Various other additives can also be applied to the mold. The coating can then be transferred to a contact lens formed within the mold such that the resulting lens has altered surface properties.

US Patent:

6793973, Sep 21, 2004

Filed:

Feb 1, 2001

Appl. No.:

09/775104

Inventors:

Lynn Cook Winterton - Alpharetta GA
John Martin Lally - Lilburn GA
Michael Rubner - Westford ME
Yongxing Qiu - Duluth GA

Assignee:

Novartis AG - Basel

International Classification:

B05D 134

US Classification:

4273935, 4274121

Abstract:

A method of forming a coating of polyionic materials in a layer-by-layer-like manner onto a polymeric material is provided. A polymeric material, such as a contact lens, can be dipped once into a solution of polyionic materials such that layers of polyionic material can be formed thereon. A single dip solution of the present invention typically contains a polyanionic material and a polycationic material in a non-stoichiometric amount and maintained within a certain pH range.

US Patent:

6811805, Nov 2, 2004

Filed:

May 22, 2002

Appl. No.:

10/154249

Inventors:

Allen Gilliard - Buford GA
Lynn Cook Winterton - Alpharetta GA
Rafael Victor Andino - Lawrenceville GA
John Lally - Lilburn GA

Assignee:

Novatis AG - Basel

International Classification:

A61L 5103

US Classification:

427 21, 427 28, 427164, 427258, 427261, 427265, 4274071, 427421, 427422, 427475, 427485, 427486, 427561, 427600

Abstract:

The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.

US Patent:

6815074, Nov 9, 2004

Filed:

May 22, 2002

Appl. No.:

10/153040

Inventors:

Celeste Aguado - Atlanta GA
Paul Clement Nicolson - Dunwoody GA
Lynn Cook Winterton - Alpharetta GA
Yongxing Qiu - Duluth GA
John Martin Lally - Lilburn GA
Jacalyn Mary Schremmer - Atlanta GA

Assignee:

Novartis AG - Basel

International Classification:

B32B 904

US Classification:

428447, 528 32, 523106, 523107, 524588, 526279, 540139, 540140, 427 224, 427162

Abstract:

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

US Patent:

6827966, Dec 7, 2004

Filed:

May 22, 2002

Appl. No.:

10/153063

Inventors:

Yongxing Qiu - Duluth GA
Fiona Patricia Carney - Atlanta GA
Nichola Kotov - Stillwater OK
John Martin Lally - Lilburn GA
Carol Ann Morris - Duluth GA
Lynn Cook Winterton - Alpharetta GA

Assignee:

Novartis AG - Basel

International Classification:

B05D 300

US Classification:

427 224, 427 21, 427 231, 427162, 427164, 427402, 4274071, 4274121, 427414, 427415, 427421, 4274301, 4273722, 4273855

Abstract:

The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

US Patent:

6852353, Feb 8, 2005

Filed:

Jul 23, 2001

Appl. No.:

09/911218

Inventors:

Yongxing Qiu - Duluth GA, US
Lynn Cook Winterton - Alpharetta GA, US
John Martin Lally - Lilburn GA, US

Assignee:

Novartis AG - Basel

International Classification:

A61L027/00
B05D001/02
B05D001/18
B05D001/36
B05D001/38

US Classification:

427 224, 427 21, 427 225, 427 228, 427 23, 427164, 427168, 427169, 4274071, 427414, 427415, 4272481, 427421, 4274301

Abstract:

The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.