Lynne L Johnson

US Patent:

20110311448, Dec 22, 2011

Filed:

Oct 31, 2008

Appl. No.:

12/734449

Inventors:

Ann Marie Schmidt - Franklin Lakes NJ, US
Lynne Johnson - New York NY, US
Barry Hudson - New York NY, US
Yared Tekabe - Yonkers NY, US

International Classification:

A61K 49/00
A61P 9/10
A61K 39/395
C07K 16/00
C07K 16/18

US Classification:

424 91, 5303879, 5303913, 5303917, 4241781

Abstract:

This invention discloses an antibody which is raised to a peptide, the sequence of which is: N-R-N-G-K-E-T-K-S-N-Y-R-V-R-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-P, S-R-N-G-K-E-T-K-S-N-Y-R-V-Q-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C, or Ac-N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C-amide. This antibody can be labeled with an imageable marker or linked to an agent. This antibody can be a monoclonal antibody. The invention also includes a method for determining the location of receptor advanced glycation endproduct (RAGE) in a subject comprising administering the antibody labeled with an imageable marker and detecting the location of the labeled antibody in the subject thereby determining the location of RAGE in the subject. This invention further describes a method for treating a RAGE-related disorder in a subject comprising administering to the subject a therapeutically effective amount of the antibody which binds to the above-described epitope linked to an agent.

US Patent:

20210008231, Jan 14, 2021

Filed:

May 19, 2017

Appl. No.:

16/303599

Inventors:

- New York NY, US
Lynne JOHNSON - New York NY, US
Monica GOLDKLANG - Demarest NJ, US
Yared TEKABE - Bronx NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 51/04
C07B 59/00

Abstract:

The present invention provides a method of imaging a subject's lung which comprises contacting the subject's lung with a matrix metalloproteinase inhibitor labeled with a radioisotope under conditions such that the inhibitor binds to matrix metalloproteinase in the lung, and then imaging the radiolabeled inhibitor bound to matrix metalloproteinase in the subject's lung.The invention also provides Ro 32-3555 labeled with a radioisotope.