Malcolm R Bell

US Patent:

40987973, Jul 4, 1978

Filed:

Jul 9, 1976

Appl. No.:

5/703949

Inventors:

Malcolm R. Bell - East Greenbush NY
Rudolf Oesterlin - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D20902

US Classification:

26032662

Abstract:

2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxyamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

US Patent:

42396875, Dec 16, 1980

Filed:

Jul 27, 1978

Appl. No.:

5/928456

Inventors:

Malcolm R. Bell - East Greenbush NY
Rudolf Oesterlin - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D20902
C07D40102

US Classification:

26032627

Abstract:

2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis of thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

US Patent:

49201280, Apr 24, 1990

Filed:

May 20, 1988

Appl. No.:

7/196598

Inventors:

Malcolm R. Bell - East Greenbush NY
James H. Ackerman - Albany NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

A61K 31415
A61K 31435
C07D41300
C07D47100

US Classification:

514293

Abstract:

Pyrazolo[3,4-b]quinolines having the formula ##STR1## where R is hydrogen, hydroxy or alkoxy; R. sub. 2 is halogen, cyano, carbamyl, carboxy, lower-alkylcarbonyl, amino or aminomethyl; and R. sub. 1 is hydrogen or selected substituents as defined herein, are useful as antiviral agents and/or as vasodilators.

US Patent:

43071023, Dec 22, 1981

Filed:

Feb 19, 1981

Appl. No.:

6/235435

Inventors:

Malcolm R. Bell - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

A61K 3144

US Classification:

424263

Abstract:

The compound of the formula ##STR1## possesses glucocorticoid activity, and is prepared by reacting the compound of the formula ##STR2## with 2-vinylpyridine.

US Patent:

42487846, Feb 3, 1981

Filed:

Feb 25, 1977

Appl. No.:

5/772004

Inventors:

Malcolm R. Bell - East Greenbush NY
Rudolf Oesterlin - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D207337

US Classification:

2603262

Abstract:

1-R. sub. 1 -4-R. sub. 4 -. alpha. ,. alpha. ,2,5-Tetramethylpyrrole-3-acetamides, useful as anti-secretory and anti-ulcer agents, are prepared by hydrolysis, in the presence of a dilute mineral acid, of a corresponding 1-R. sub. 1 -4-R. sub. 4 -. alpha. ,. alpha. ,2,5-tetramethylpyrrole-3-acetonitrile.

US Patent:

39681211, Jul 6, 1976

Filed:

Jan 13, 1975

Appl. No.:

5/540550

Inventors:

Malcolm R. Bell - East Greenbush NY
Andrew W. Zalay - Albany NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D20908
C07D20912

US Classification:

26032613R

Abstract:

This invention relates to novel 1-[4-(R. sub. 1 R. sub. 2 N-C. sub. n H. sub. 2n -O)phenyl]-5-R. sub. 4 -2-(4-R. sub. 3 -phenyl)indoles having antifertility and hypocholesterolemic activities and to novel intermediates for their preparation.

US Patent:

41119460, Sep 5, 1978

Filed:

Jul 29, 1977

Appl. No.:

5/820402

Inventors:

Karl O. Gelotte - Nassau NY
Andrew W. Zalay - Albany NY
Malcolm R. Bell - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D21346

US Classification:

260297R

Abstract:

3-(4- OR 3-Pyridinyl)-2-cyclohexen-1-ones (I) and their oxime derivatives are useful in preparing (3-aminophenyl)-pyridines, in turn, useful in preparing known antibacterial agents. Also shown is the preparation of I by starting with the reaction of methyl vinyl ketone with either 1-(pyridinyl)-1-(lower-tertiary-amino)-ethylene (II) or lower-alkyl 3-(pyridinyl)-3-oxopropanoate. Also shown is the process of converting I to its oxime, acylating the oxime and heating the acylated oxime under acidic conditions to produce N-(lower-acyl)-3-(pyridinyl)-aniline (VII), and hydrolyzing VII under aqueous alkaline conditions to produce the corresponding 3-(pyridinyl)aniline.

US Patent:

50682342, Nov 26, 1991

Filed:

Feb 26, 1990

Appl. No.:

7/484759

Inventors:

Thomas E. D'Ambra - North Greenbush NY
Edward R. Bacon - East Greenbush NY
Malcolm R. Bell - East Greenbush NY
Philip M. Carabateas - Schodack NY
Michael A. Eissenstat - West Sand Lake NY
Virendra Kumar - Colonie NY
John P. Mallamo - Kinderhook Township, Columbia County NY
Susan J. Ward - East Greenbush NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D41706
C07D41306
A61K 3154
A61K 31535

US Classification:

5142352

Abstract:

2-R. sub. 2 -R. sub. 4 -substituted-3-R. sub. 3 -CO-1-[(C-attached-N-herteryl)-(Alk). sub. n ]-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.