Malcolm H Randall

US Patent:

6437141, Aug 20, 2002

Filed:

Apr 2, 2001

Appl. No.:

09/824316

Inventors:

Malcolm Harry Randall - Wayland MA
Philip Richard Buzby - Brockton MA
Thomas Joseph Erickson - Carlisle MA
Joseph David Trometer - Framingham MA
David George Ahern - Lexington MA
Mark Norman Bobrow - Lexington MA

Assignee:

NEN Life Science Products, Inc. - Boston MA

International Classification:

C07D27904

US Classification:

548152, 544105, 544349, 544 51, 544 73, 5462701, 5462717, 5462734, 5462774, 548156, 548159, 548217, 548219, 5483051, 5483054, 548455

Abstract:

A cyanine dye having the formula wherein R -R are each independently selected from a group consisting of hydrogen, C -C alkyl group, and C -C alkyl group having a hydrophilic substituent thereon. R and R are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

US Patent:

62043897, Mar 20, 2001

Filed:

Nov 24, 1999

Appl. No.:

9/448241

Inventors:

Malcolm Harry Randall - Wayland MA
Philip Richard Buzby - Brockton MA
Thomas Joseph Erickson - Carlisle MA
Joseph David Trometer - Framingham MA
Joseph John Miller - Dracut MA
David George Ahern - Lexington MA
Mark Norman Bobrow - Lexington MA

Assignee:

NEN Life Science Products, Inc. - Boston MA

International Classification:

C07D27904
C07D41704
C07D27762
C07D27760
C07D26352

US Classification:

548152

Abstract:

A cyanine dye having the formula ##STR1## wherein R. sub. 1 --R. sub. 8 are each independently selected from a group consisting of hydrogen, C. sub. 1 -C. sub. 6 alkyl group, and C. sub. 0 -C. sub. 4 alkyl group having a hydrophilic substituent thereon. R. sub. 11 and R. sub. 12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

US Patent:

61143502, Sep 5, 2000

Filed:

Apr 19, 1999

Appl. No.:

9/294678

Inventors:

Malcolm Harry Randall - Wayland MA
Philip Richard Buzby - Brockton MA
Thomas Joseph Erickson - Carlisle MA
Joseph David Trometer - Framingham MA
Joseph John Miller - Dracut MA
David George Ahern - Lexington MA
Mark Norman Bobrow - Lexington MA

Assignee:

NEN Life Science Products, Inc. - Boston MA

International Classification:

A61K 3147
A61K 31425
C07D27916
C07D21504
C07D27760

US Classification:

514311

Abstract:

A cyanine dye having the formula ##STR1## wherein R. sub. 1 -R. sub. 8 are each independently selected from a group consisting of hydrogen, C. sub. 1 -C. sub. 6 alkyl group, and C. sub. 0 -C. sub. 4 alkyl group having a hydrophilic substituent thereon. R. sub. 11 and R. sub. 12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

US Patent:

61979562, Mar 6, 2001

Filed:

Nov 24, 1999

Appl. No.:

9/449333

Inventors:

Malcolm Harry Randall - Wayland MA
Philip Richard Buzby - Brockton MA
Thomas Joseph Erickson - Carlisle MA
Joseph David Trometer - Framingham MA
Joseph John Miller - Dracut MA
David George Ahern - Lexington MA
Mark Norman Bobrow - Lexington MA

Assignee:

NEN Life Science Products, Inc. - Boston MA

International Classification:

C07D27916
C07D24136
C07D41704
C07D27760
C07D40302

US Classification:

544 51

Abstract:

A cyanine dye having the formula ##STR1## wherein R. sub. 1 -R. sub. 8 are each independently selected from a group consisting of hydrogen, C. sub. 1 -C. sub. 6 alkyl group, and C. sub. 0 -C. sub. 4 alkyl group having a hydrophilic substituent thereon. R. sub. 11 and R. sub. 12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

US Patent:

62246445, May 1, 2001

Filed:

Nov 24, 1999

Appl. No.:

9/448242

Inventors:

Malcolm Harry Randall - Wayland MA
Philip Richard Buzby - Brockton MA
Thomas Joseph Erickson - Carlisle MA
Joseph David Trometer - Framingham MA
Joseph John Miller - Dracut MA
David George Ahern - Lexington MA
Mark Norman Bobrow - Lexington MA

Assignee:

NEN Life Science Products, Inc. - Boston MA

International Classification:

C07D27904
C07D41704
C07D27762
C07D27760
C07D26352

US Classification:

48152

Abstract:

A cyanine dye having the formula ##STR1## wherein R. sub. 1 -R. sub. 8 are each independently selected from a group consisting of hydrogen, C. sub. 1 -C. sub. 6 alkyl group, and C. sub. 0 -C. sub. 4 alkyl group having a hydrophilic substituent thereon. R. sub. 11 and R. sub. 12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.