Malik Y Kahook

US Patent:

20120116504, May 10, 2012

Filed:

Mar 16, 2010

Appl. No.:

13/257196

Inventors:

Michael B. Lyons - Boulder CO, US
Julie Marie Trommeter - Lafayette CO, US
Naresh Mandava - Denver CO, US
Malik Kahook - Denver CO, US
Robin Shandas - Boulder CO, US
James Fogelberg - Boulder CO, US
Jeffrey Paul Castleberry - Longmont CO, US

Assignee:

The Regents of the University of Colorado - Denver CO
EndoShape, Inc. - Boulder CO

International Classification:

A61F 2/14

US Classification:

623 41

Abstract:

An implantable ophthalmological device () in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device () may include an elongated body (), an anchor () operably connected to the elongated body (), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (), and a flange (). The elongated body () may define a lumen () configured to receive a pharmacological treatment (). The device () is made of a shape memory material such as a shape memory polymer.

US Patent:

20120203160, Aug 9, 2012

Filed:

Oct 12, 2010

Appl. No.:

13/501599

Inventors:

Malik Y. Kahook - Denver CO, US
Naresh Mandava - Denver CO, US
Robin Shandas - Boulder CO, US
Bryan Rech - Boulder CO, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE - Denver CO

International Classification:

A61F 9/007

US Classification:

604 8

Abstract:

The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.

US Patent:

20120232648, Sep 13, 2012

Filed:

Apr 6, 2012

Appl. No.:

13/441764

Inventors:

Malik Y. Kahook - Denver CO, US
Naresh Mandava - Denver CO, US
Robin Shandas - Boulder CO, US
Bryan Rech - Boulder CO, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE - Denver CO

International Classification:

A61F 2/16
A61F 2/14

US Classification:

623 516, 623 611, 623 656, 623 511

Abstract:

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10 C. and 60 C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

US Patent:

20120232651, Sep 13, 2012

Filed:

Apr 6, 2012

Appl. No.:

13/441754

Inventors:

Malik Y. Kahook - Denver CO, US
Naresh Mandava - Denver CO, US
Robin Shandas - Boulder CO, US
Bryan Rech - Boulder CO, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE - Denver CO

International Classification:

A61F 2/16

US Classification:

623 656

Abstract:

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10 C. and 60 C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

US Patent:

20130149734, Jun 13, 2013

Filed:

May 31, 2011

Appl. No.:

13/700682

Inventors:

David Ammar - Denver CO, US
Malik Kahook - Denver CO, US
Tim Lei - Thornton CO, US
Emily Gibson - Boulder CO, US
Omid Masihzadeh - Lakewood CO, US
Naresh Mandava - Denver CO, US

Assignee:

The Regents of the University of Colorado, a body corporate - Denver CO

International Classification:

A61B 3/00
G01N 21/65
G01N 21/64

US Classification:

435 29, 600476, 2504581, 356 73, 2504591

Abstract:

A multimodal method for imaging tissue comprising: aligning an excitation light source with at least a portion of the tissue; selecting at least two modalities of image acquisition; imaging the tissue portion with each of the modalities of image acquisition; and constructing a dual mode image using images from each of the modalities of image acquisition. A multimodal system for imaging tissue comprising: an excitation light source or light sources; an optical and alignment system for directing the excitation beam or beams to a sample and receiving an emission beam from the sample; at least one detector for receiving the emission beam from the sample; and a spectral filtering or dispersing device for providing at least two imaging modalities at the at least one detector; and a processor for analyzing the detected emission beam and constructing a dual mode image using images from each of the modalities of image acquisition.

US Patent:

20130190868, Jul 25, 2013

Filed:

Jan 23, 2013

Appl. No.:

13/748207

Inventors:

Malik Y. Kahook - Denver CO, US
Naresh Mandava - Denver CO, US
Paul McLean - North Oaks MN, US
Robert E. Atkinson - White Bear Lake MN, US

International Classification:

A61F 2/16

US Classification:

623 641, 623 638

Abstract:

A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.

US Patent:

20130218178, Aug 22, 2013

Filed:

Sep 12, 2011

Appl. No.:

13/821907

Inventors:

Robin Shandas - Boulder CO, US
Craig Joseph Lanning - Denver CO, US
Robyn Grace Yeon Glang - Colorado Springs CO, US
Bryan Andrew Rech - Boulder CO, US
Naresh Mandava - Denver CO, US
Malik Kahook - Denver CO, US
Nageswara Rao Mandava - Jamaica NY, US

Assignee:

The Regents of the University of Colorado, A Body Corporate - Denver CO

International Classification:

A61F 2/00

US Classification:

606151

Abstract:

Formulations of shape memory polymer (SMP) are integrated with several existing clinically available medical fabrics. The SMP portion of a SMP-integrated fabric can be fabricated in varying thicknesses with the minimum thickness determined by the thickness of the underlying fabric and up to almost any thickness. A large variety of patterns may be formed in SMP-integrated fabrics based upon how the shape memory polymer is integrated into the base fabric. Integration of the SMP with the base fabrics does not alter the shape memory functionality of the SMP. The design tools for controlling activation rate for traditional SMP materials thus apply to SMP-integrated fabrics. SMP-integrated fabrics may also be steam sterilized without loss of shape memory functionality. By using multiple formulations of SMP on a single piece of fabric, a large combination of material properties may be provided within a single SMP-integrated fabric device.

US Patent:

20130267887, Oct 10, 2013

Filed:

Sep 21, 2011

Appl. No.:

13/825495

Inventors:

Malik Kahook - Denver CO, US
Naresh Mandava - Denver CO, US
Robin Shandas - Boulder CO, US
Bryan Rech - Boulder CO, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF COLORADO - Denver CO

International Classification:

A61F 9/007
B29C 53/02

US Classification:

604 9, 604 8, 264320, 264241

Abstract:

A small shunt can be placed within the eye to aid in drainage of aqueous humor from the anterior chamber of the eye to a pocket between the conjunctiva and the sclera to be absorbed, or to secrete through the cornea or the sclera external to the eye for glaucoma or ocular hypertension treatment. This drainage can decrease the pressure of the eye and potentially modify the course of advancing glaucomatous optic neuropathy as it relates to eye pressure. The shunt is formed of a shape memory polymer material and deformed into a smaller form factor to reduce trauma to the eye resulting from the insertion of the shunt through the sclera to the anterior chamber. Once in situ, the shunt deploys in response to body heat or other external stimulus and expands to its original, larger form factor to provide a secure friction fit of the shunt within the scleral tissue and to enlarge the lumen of the shunt to allow for aqueous flow.