Manoj Nm Kumar

US Patent:

6720168, Apr 13, 2004

Filed:

Aug 3, 2001

Appl. No.:

09/922501

Inventors:

Veronique A. Dartois - San Diego CA
James A. Hoch - La Jolla CA
Fernando Valle - Burlingame CA
Manoj Kumar - Fremont CA

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

C12P 1900

US Classification:

435 72, 435320 N, 435252 B, 43525233, 536 272

Abstract:

The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, which can subsequently be converted to ascorbic acid. Further provided are isolated polypeptides having 2,5-DKG permease activity, immunogenic peptides therefrom, and antibodies specific therefor. The invention also provides methods of identifying novel 2,5-DKG permeases.

US Patent:

7229795, Jun 12, 2007

Filed:

Feb 25, 2004

Appl. No.:

10/787267

Inventors:

Veronique A. Dartois - San Diego CA, US
James A. Hoch - La Jolla CA, US
Fernando Valle - Burlingame CA, US
Manoj Kumar - Fremont CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA
E.P.I. Liquidation Co. - La Jolla CA

International Classification:

C12P 19/00
C12N 1/20

US Classification:

435 72, 4352523, 4353201, 435183, 536 232, 536 237

Abstract:

The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, which can subsequently be converted to ascorbic acid. Further provided are isolated polypeptides having 2,5-DKG permease activity, immunogenic peptides therefrom, and antibodies specific therefor. The invention also provides methods of identifying novel 2,5-DKG permeases.

US Patent:

20210205321, Jul 8, 2021

Filed:

Feb 21, 2019

Appl. No.:

15/733535

Inventors:

- La Jolla CA, US
Emily Chin - San Diego CA, US
Arnab K. Chatterjee - San Diego CA, US
Manoj Kumar - San Diego CA, US
Ana Maria Gamo Albero - La Jolla CA, US
Hank Michael James Petrassi - San Diego CA, US
Peter G. Schultz - La Jolla CA, US
Chenguang Yu - La Jolla CA, US
Junko Tamiya - Carlsbad CA, US
William Vernier - Vista CA, US
Anil Gupta - San Diego CA, US
Ramkumar Modukuri - Houston TX, US

International Classification:

A61K 31/5365
A61K 31/501
A61K 31/536
A61K 31/506
A61K 45/06
A61K 9/00
A61K 9/127
A61K 47/68

Abstract:

The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (I): as defined herein. Compounds for practice of a method of the invention can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immune-checkpoint targeting drug.

US Patent:

20200024290, Jan 23, 2020

Filed:

Mar 14, 2018

Appl. No.:

16/495907

Inventors:

- La Jolla CA, US
Chao Li - San Diego CA, US
Jie Wang - San Diego CA, US
Arnab Kumar Chatterjee - San Diego CA, US
Manoj Kumar - San Diego CA, US
Shan Yu - San Diego CA, US
Kristen Ann Johnson - Santee CA, US
Tian Qin - Dallas TX, US
Ming Shang - San Diego CA, US

International Classification:

C07F 5/02
C07B 47/00
B01J 31/02
C07K 7/64

Abstract:

The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(11) salt or a copper salt, and an Mg(11) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009.

US Patent:

20170144998, May 25, 2017

Filed:

Dec 16, 2016

Appl. No.:

15/381507

Inventors:

- La Jolla CA, US
Manoj KUMAR - San Diego CA, US
Peter G. SCHULTZ - La Jolla CA, US

International Classification:

C07D 405/14
C07D 401/14
C07D 213/82
C07D 207/16

Abstract:

Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.

US Patent:

20160159754, Jun 9, 2016

Filed:

Jul 2, 2014

Appl. No.:

14/900355

Inventors:

- La Jolla CA, US
Arnab K. CHATTERJEE - San Diego CA, US
Manoj KUMAR - San Diego CA, US
Gustav WELZEL - San Diego CA, US

International Classification:

C07D 241/32
C07D 241/28
C07C 279/18

Abstract:

Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.