Manoj K Kumar

US Patent:

6358715, Mar 19, 2002

Filed:

Dec 4, 1998

Appl. No.:

09/205874

Inventors:

Manoj Kumar - Fremont CA

Assignee:

Genencor International, Inc. - Rochester NY

International Classification:

C12P 762

US Classification:

435138, 435135, 435136, 435143, 4352523, 4352524, 435171

Abstract:

The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source.

US Patent:

6808918, Oct 26, 2004

Filed:

Dec 18, 2001

Appl. No.:

10/026586

Inventors:

Manoj Kumar - Fremont CA

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

C12N 114

US Classification:

4352554, 435 4, 435 6, 435 25, 435 29, 435 691, 435 41, 435135 T, 435183 T, 435189 T, 4352523, 4352551, 4352553, 4353201, 435262, 536 232 T

Abstract:

The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source.

US Patent:

6824996, Nov 30, 2004

Filed:

Dec 18, 2001

Appl. No.:

10/026139

Inventors:

Manoj Kumar - Fremont CA

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

G01N 3353

US Classification:

435 731, 435 4, 435 72, 435 30, 435 34, 435 41, 435138, 435148, 435243, 4352541, 4352542, 43525422, 4352553

Abstract:

The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast capable of producing ASA from a carbon source.

US Patent:

7229811, Jun 12, 2007

Filed:

Aug 3, 2001

Appl. No.:

10/343369

Inventors:

Manoj Kumar - Fremont CA, US
Fernando Valle - Burlingame CA, US
Veronique A. Dartois - San Diego CA, US
James A. Hoch - La Jolla CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA
E.P.I. Liquidation Co. - La Jolla CA

International Classification:

C07H 21/04
C12N 15/00
C12N 1/20
C12P 7/40
C12P 21/06
C12Q 1/26
C07K 14/00
C12P 19/34
C12N 9/04

US Classification:

435190, 435 691, 435 25, 4353201, 4352523, 435136, 435 911, 536 231, 536 232, 530350

Abstract:

The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, which can subsequently be converted to ascorbic acid. Further provided are isolated polypeptides having 2,5-DKG permease acitivity, immunogenic peptides therefrom, and antibodies specific therefor. The invention also provides methods of identifying novel 2,5-DKG permeases.

US Patent:

7297678, Nov 20, 2007

Filed:

Mar 12, 2004

Appl. No.:

10/800179

Inventors:

Manoj Kumar - Fremont CA, US
William A. Cuevas - San Francisco CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

A61K 38/00
C07K 2/00

US Classification:

514 2, 530300

Abstract:

A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.

US Patent:

7381789, Jun 3, 2008

Filed:

May 20, 2003

Appl. No.:

10/441965

Inventors:

Manoj Kumar - Fremont CA, US

Assignee:

Genencor International, Inc. - Alto CA

International Classification:

C07K 17/00

US Classification:

530300, 530420, 977715

Abstract:

Methods for forming repeat protein polymers and utilizing the repeat protein polymers to form inorganic structures are provided. The inorganic structures may have features on the nanoscale, and the structures generally do not have the repeat protein polymer incorporated therein.

US Patent:

7419795, Sep 2, 2008

Filed:

May 10, 2004

Appl. No.:

10/842929

Inventors:

Timothy C. Dodge - Sunnyvale CA, US
Manoj Kumar - Fremont CA, US
M. Harunur Rashid - Sunnyvale CA, US
Fernando Valle - Burlingame CA, US

Assignee:

Danisco A/S, Genencor Division - Palo Alto CA

International Classification:

G01N 33/53

US Classification:

435 76, 435 71, 435137, 514 2, 514 12

Abstract:

The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.

US Patent:

7456147, Nov 25, 2008

Filed:

May 14, 2004

Appl. No.:

10/845775

Inventors:

Manoj Kumar - Fremont CA, US
Isabelle Mazeaud - Chatellerault, FR
Steven Patrick Christiano - Midland MI, US

Assignee:

Dow Corning, Corporation - Midland MI
Genencor International, Inc. - Palo Alto CA

International Classification:

A61K 38/00
C07K 2/00

US Classification:

514 2, 530300

Abstract:

Systems are provided for the controlled release delivery of active agents through the use of repeat sequence protein polymers. The systems may exist as matrices, gels, hydrogels, films, emulsions or microparticles and are particularly useful for incorporating active agents into personal care product compositions.