Manuel Baca - Foster City CA, US James A. Wells - Burlingame CA, US Leonard G. Presta - San Francisco CA, US Henry B. Lowman - El Granada CA, US Yvonne Man-yee Chen - San Mateo CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39/395
US Classification:
4241331, 4241561, 5303873, 53038885
Abstract:
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
Manuel Baca - Foster City CA, US James A. Wells - Burlingame CA, US Leonard G. Presta - San Francisco CA, US Henry B. Lowman - El Granada CA, US Yvonne Man-yee Chen - San Mateo CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39/395
US Classification:
4241301, 4353201, 5303873, 53038885, 536 2353
Abstract:
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
High Affinity Antibody Antagonists Of Interleukin-13 Receptor Alpha 1
Andrew Donald Nash - Kew, AU Manuel Baca - Gaithersburg MD, US Louis Jerry Fabri - Diamond Creek, AU Dennis Zaller - Scotch Plains NJ, US William R. Strohl - Bridgewater NJ, US Zhiqiang An - Ambler PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ CSL Limited - Parkville, Victoria
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
Methods Of Treating Inflammatory Airway Conditions By Inhibition Of Il-11 Activity
The present invention relates generally to the treatment of an interleukin-11 (IL-11)-mediated condition. More particularly, the present invention provides the use of modified forms of IL-11 which modulate IL-11 signaling in the treatment of IL-11-mediated conditions.
High Affinity Antibody Antagonists Of Interleukin-13 Receptor Alpha 1
Andrew Donald Nash - Kew, AU Manuel Baca - Gaithersburg MD, US Louis Jerry Fabri - Diamond Creek, AU Dennis Zaller - Scotch Plains NJ, US William R. Strohl - Bridgewater NJ, US Zhiqiang An - Ambler PA, US
Assignee:
CSL Limited - Parkville, Victoria
International Classification:
A61K 39/395
US Classification:
4241441
Abstract:
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
Andrew Donald Nash - Kew, AU Manuel Baca - Gaithersburg MD, US Louis Jerry Fabri - Diamond Creek, AU Dennis Zaller - Scotch Plains NJ, US William R. Strohl - Bridgewater NJ, US Zhiqiang An - Ambler PA, US
Assignee:
CSL Limited - Parkville, Victoria
International Classification:
A61K 39/395
US Classification:
4241441
Abstract:
Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13Rα1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13Rα1-mediated activities are also disclosed.
Gilead Sciences
Senior Director, Biologics Discovery
Juno Therapeutics, Inc. Aug 2016 - May 2017
Head of Cell and Protein Science
Medimmune Jan 2007 - Aug 2016
Fellow 2011-2016; Principal Scientist 2007-2011
Zenyth Therapeutics/Amrad Corp Jan 2004 - Jan 2007
Head of Antibody Technology
Walter and Eliza Hall Institute of Medical Research 1997 - 2003
Research Fellow, Lab Head
Education:
Scripps Research 1994
Scripps Research 1991 - 1994
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry
Unsw 1989
Bachelors, Bachelor of Science
University of Sydney 1984 - 1988
Bachelors, Bachelor of Science, Chemistry
Skills:
Protein Chemistry Antibodies Drug Development Protein Engineering Life Sciences Monoclonal Antibodies Biotechnology Biologics Drug Discovery Cancer Phage Display Molecular Biology Cell Signaling Protein Purification Biochemistry Assay Development Biopharmaceuticals Immunology Chemistry Protein Expression Purification Peptide Chemistry Analytical Biochemistry Technology Transfer
"We want to impose a 100-unit limit so that if students don't complete their work, they'll have to pay full cost, around $200 a unit," said Manuel Baca, a task force member who serves on the Community College Board of Governors.