Marc G Apple

US Patent:

6494824, Dec 17, 2002

Filed:

Feb 20, 1999

Appl. No.:

09/253310

Inventors:

Marc G. Apple - Fort Wayne IN 47906
Brian L. Bates - Bloomington IN
John A. DeFord - Bloomington IN
Neal E. Fearnot - West Lafayette IN
James D. Purdy - Lafayette IN
Joseph P. Lane - Bloomington IN
Delbert C. Miller - Bloomington IN
Gregory A. Frankland - Unionville IN

Assignee:

Marc G. Apple - Ft. Wayne IN

International Classification:

A61N 0500

US Classification:

600 3

Abstract:

A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. A radiotherapy source vial ( ) includes a fluid container ( ) of radioactive fluid with a seal ( ) disposed about the container. Seal ( ) is moveable with respect to container ( ) to change the contained volume therein. A radioactive fluid transport site ( ) is in communication with the contained volume and with an exterior ( ) of the container ( ), and may include a septum ( ) or a valve ( ). An engagement mechanism ( ) is connectable to an external control mechanism ( ) whereby the contained volume in the radioactive fluid container can be decreased and increased by actuation of the external control mechanism.

US Patent:

7029431, Apr 18, 2006

Filed:

Apr 24, 2003

Appl. No.:

10/421032

Inventors:

Melvin J. Apple - Boca Raton FL, US
Marc G. Apple - Fort Wayne IN, US

International Classification:

A61N 5/00

US Classification:

600 3

Abstract:

The directional-ionizing energy emitting implant is for attachment either to natural tissue or a prosthetic device, and delivers a prescribed dosage of energy to targeted tissue. The insert device includes an energy-source material within the insert device that delivers the prescribed dosage of energy to the targeted tissue, while minimizing exposure of nontargeted tissue. The targeted tissue has a known energy-response profile and is adjacent to the targeted tissue. The energy-source material in combination with the prosthetic device defines an actual energy-delivery distribution field. The energy-delivery distribution field has a configuration similar to the known energy-responsive profile of the targeted tissue. The prescribed dosage of energy is applied from energy-source material within the insert device and directed to the targeted tissue. The prescribed energy dosage is determined by using known characteristics of the energy-source material, and by the placement of the energy-source material relative to the targeted tissue.

US Patent:

7182726, Feb 27, 2007

Filed:

Apr 24, 2003

Appl. No.:

10/421141

Inventors:

John I. Williams - Fort Wayne IN, US
Marc G. Apple - Fort Wayne IN, US

International Classification:

A61N 5/00

US Classification:

600 3

Abstract:

The present invention provides a system and method of applying low dose, localized radiotherapy which is effective to reduce or eliminate the formation of post-operative scar tissue at surgical sites, such as an epidural site after spinal surgery. In an exemplary embodiment, a device is implantable before closing a surgical site as a barrier, the device being designed to deliver a desired therapeutic amount of energy to particular tissue. The device can be a barrier layer, seed containment unit, radiospike, or catheter. The energy may be provided by the material of the device itself, or may be provided by an external source, such as by circulating radioactive fluid through the device itself. Various embodiments include additional components of the device which deliver drug or chemical agents to targeted tissue and/or shield components to prevent dosage to non-targeted tissue.

US Patent:

20020022799, Feb 21, 2002

Filed:

Dec 26, 2000

Appl. No.:

09/748327

Inventors:

Marc Apple - Fort Wayne IN, US

International Classification:

A61M029/00

US Classification:

604/096010

Abstract:

A balloon catheter assembly () including a balloon section (), a radiofluid port (), and a magnetizing section. The magnetizing section generates a magnetic field that enhances the energy of the electrons (Beta particles) from radiofluid within the balloon section to increase the depth dose. The magnetizing section may comprise a solenoid arrangement () wherein wires () within catheter wall () having coils () surrounding the catheter within the balloon section () are connected to a controlled source () of milliamperage or microamperage, and generate a magnetic field within balloon section (). Permanently magnetized distal end portions () of the catheter () or guide wire () or both, within balloon section (), may be used to generate the magnetic field, or may be used in conjunction with a solenoid arrangement.

US Patent:

20060106273, May 18, 2006

Filed:

Nov 4, 2005

Appl. No.:

11/267344

Inventors:

Marc Apple - Fort Wayne IN, US

International Classification:

A61M 36/04

US Classification:

600003000

Abstract:

The directional-ionizing energy emitting implant is for attachment either to natural tissue or a prosthetic device, and delivers a prescribed dosage of energy to targeted tissue. The insert device includes an energy-source material within the insert device that delivers the prescribed dosage of energy to the targeted tissue, while minimizing exposure of nontargeted tissue. The targeted tissue has a known energy-response profile and is adjacent to the targeted tissue. The energy-source material in combination with the prosthetic device defines an actual energy-delivery distribution field. The energy-delivery distribution field has a configuration similar to the known energy-responsive profile of the targeted tissue. The prescribed dosage of energy is applied from energy-source material within the insert device and directed to the targeted tissue. The prescribed energy dosage is determined by using known characteristics of the energy-source material, and by the placement of the energy-source material relative to the targeted tissue. The implant system reduces any occurrence of heterotopic ossification caused by the implant, inhibits growth or migration of benign or malignant living cells, and minimizes or even eliminates infectious processes or delayed keloid or scar formation induced from surgical placement of a functional prosthesis or fixation device, in tissue within or about the device due to its targeted therapeutic energy emission effects.

US Patent:

61591416, Dec 12, 2000

Filed:

Sep 11, 1998

Appl. No.:

9/150814

Inventors:

Marc G. Apple - Fort Wayne IN
Brian L. Bates - Bloomington IN
John A. DeFord - Bloomington IN
Neal E. Fearnot - West Lafayette IN

Assignee:

Cook Incorporated - Bloomington IN
Med Institute Inc. - West Lafayette IN

International Classification:

A61N 500

US Classification:

600 3

Abstract:

A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall.

US Patent:

61205400, Sep 19, 2000

Filed:

Jan 21, 1999

Appl. No.:

9/234965

Inventors:

Marc G. Apple - Fort Wayne IN
Melvin J. Apple - Boca Raton FL

International Classification:

A61F 202

US Classification:

623 1111

Abstract:

An implant system and a method for delivering a dosage of radiation to targeted tissue. The system comprises a prosthetic device that functionally replaces or is additive to a body structure or joint, and a radio source material. The radio source material is positioned either on or within the prosthetic device. The actual radiation delivery distribution field has a similar configuration to the profile of the targeted tissue. The implant system is particularly useful for inhibiting heterotopic ossification.

US Patent:

62510592, Jun 26, 2001

Filed:

Mar 4, 1999

Appl. No.:

9/262620

Inventors:

Marc G. Apple - Fort Wayne IN
Brian L. Bates - Bloomington IN
John A. DeFord - Bloomington IN
Neal E. Fearnot - West Lafayette IN

Assignee:

Cook Incorporated - Bloomington IN
MED Institute, Inc. - West Lafayette IN

International Classification:

A61N 500

US Classification:

600 3

Abstract:

A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall.